{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T20:33:23Z","timestamp":1767990803959,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002802","name":"Cardiff Metropolitan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002802","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2025,12]]},"abstract":"Abstract<\/jats:title>\n \n Background and Objectives<\/jats:title>\n \n Platelet transfusions are essential for mitigating the bleeding risk of neonatal patients with thrombocytopenia. As neonatal patients have a small blood volume, adult therapeutic dose platelet units are split into reduced\u2010volume storage containers to maximize the use of the donated product and reduce donor exposure. The shelf\u2010life of platelets stored in reduced\u2010volume containers, however, is limited to 5\u2009days. Agitation in platelet concentrate (PC) storage is thought to promote gaseous exchange by maintaining a gradient of O\n 2<\/jats:sub>\n across the bag film; however, recent studies have shown that agitation\u2010induced shear promotes the progressive decline of platelet quality over storage.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n Electron paramagnetic resonance oximetry and Fickian diffusion modelling of O\n 2<\/jats:sub>\n were used to investigate the differences in O\n 2<\/jats:sub>\n availability, by assessing the O\n 2<\/jats:sub>\n concentration, oxygen consumption rate (OCR), influx of O\n 2<\/jats:sub>\n , total PC OCR and O\n 2<\/jats:sub>\n distribution in PCs stored under routine conditions in neonatal (Macopharma, VQE605B) versus adult (Haemonetics, ATSBC1ESE) PC storage containers. The influence of agitation on neonatal PC storage was evaluated.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Results indicate neonatal PCs experience significantly higher O\n 2<\/jats:sub>\n availability compared to adult PCs and can withstand greater insult to their ambient O\n 2<\/jats:sub>\n concentration. Adjusting the agitation frequency of neonatal PCs stored from 20 to 400\u2009rpm had no detrimental effect on O\n 2<\/jats:sub>\n availability, compared to storage at 60\u2009rpm.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Neonatal PCs can maintain higher O\n 2<\/jats:sub>\n availability and tolerate reduced agitation without compromising oxygenation; therefore, reduced agitation strategies may be a feasible option to minimize shear during storage without compromising O\n 2<\/jats:sub>\n availability.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/vox.70101","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:28:59Z","timestamp":1756427339000},"page":"1232-1241","source":"Crossref","is-referenced-by-count":1,"title":["Enhanced\n \n O\n 2<\/sub>\n <\/scp>\n availability in platelet concentrates stored for neonatal transfusion is independent of agitation: Evidence from direct oximetry and Fickian diffusion modelling"],"prefix":"10.1111","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2592-1090","authenticated-orcid":false,"given":"Dean","family":"Pym","sequence":"first","affiliation":[{"name":"Centre of Cardiovascular Health and Ageing Cardiff Metropolitan University Cardiff UK"},{"name":"Welsh Blood Service, Component Development and Research Laboratory Pontyclun UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleg","family":"Grinberg","sequence":"additional","affiliation":[{"name":"Dartmouth Medical School Hanover New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda J.","family":"Davies","sequence":"additional","affiliation":[{"name":"Centre of Cardiovascular Health and Ageing Cardiff Metropolitan University Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica O.","family":"Williams","sequence":"additional","affiliation":[{"name":"Centre of Cardiovascular Health and Ageing Cardiff Metropolitan University Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7010-6068","authenticated-orcid":false,"given":"Christine","family":"Saunders","sequence":"additional","affiliation":[{"name":"Welsh Blood Service, Component Development and Research Laboratory Pontyclun UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chlo\u00eb E.","family":"George","sequence":"additional","affiliation":[{"name":"Welsh Blood Service, Component Development and Research Laboratory Pontyclun UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip E.","family":"James","sequence":"additional","affiliation":[{"name":"Centre of Cardiovascular Health and Ageing Cardiff Metropolitan University Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14233"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2016.05.009"},{"key":"e_1_2_9_4_1","first-page":"715","article-title":"The methods of diagnostic of immune thrombocytopenia of fetus and newborn","volume":"61","author":"Butina EV","year":"2016","journal-title":"Klin Lab Diagn"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)81059-9"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12528"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2024.2389967"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000140239.43116.30"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12452"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2011.03.005"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V60.1.194.194"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V46.2.209.209"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1983.tb01918.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106504"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V64.2.406.406"},{"key":"e_1_2_9_16_1","volume-title":"Biochemistry, anaerobic glycolysis","author":"Melkonian EA","year":"2025"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1993.tb02147.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.18101"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-021-00359-7"},{"key":"e_1_2_9_20_1","unstructured":"Joint United Kingdom (UK) Blood Transfusion and Tissue Transplantation Services Professional Advisory Committee.Guidelines for the Blood Transfusion Services in the UK 2022. Available from:https:\/\/www.transfusionguidelines.org\/red-book\/chapter-8-evaluation-of-novel-blood-components-production-processes-and-blood-packs-generic-protocols\/8-3-evaluation-of-new-platelet-components-for-transfusion. 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