{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:17:07Z","timestamp":1790295427769,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Blood transfusion is essential in healthcare but carries inherent risks of human immunodeficiency virus\u00a0(HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), syphilis and malaria transmission. National sero\u2010epidemiology data on major transfusion\u2010transmitted infections (TTI) in blood donors are lacking in India. This review aimed to estimate the prevalence of TTI in India, examine zonal variations, assess donor demographics and testing methodologies and analyse prevalence trends to further provide recommendations for blood safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A systematic search of all original articles published in India from January 2019 to January 2024 in MEDLINE, SCOPUS, CINAHL and Google Scholar databases was conducted by following Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses (PRISMA) criteria. Data regarding donor demographics, zonal distribution and TTI prevalence were retrieved from the studies after methodological evaluation. Meta\u2010analysis was performed by the binary random\u2010effects model. The risk of bias and publication bias were assessed utilizing RStudio.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis included 41 studies with 1,860,594 blood donors. The pooled prevalence rates for HIV, HBV, HCV, syphilis and malaria among Indian blood donors were 0.12%, 0.91%, 0.28%, 0.14% and 0.01%, respectively. Males, replacement donors and first\u2010time donors had a higher prevalence compared to females, voluntary donors and repeat donors, respectively. HIV (0.18%) and HCV (0.83%) were most prevalent in the North\u2010east, HBV (1.57%) in the Central, syphilis (0.48%) in the North and malaria (0.04%) in the East zone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This review highlighted the influence of donor demographics and testing methodologies on TTI prevalence, emphasizing zonal disparities, with findings laying the groundwork for policy development and future research to improve blood supply reliability.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.70102","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:39:07Z","timestamp":1756687147000},"page":"958-968","source":"Crossref","is-referenced-by-count":5,"title":["Seroprevalence of transfusion\u2010transmitted infections among blood donors in India: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6020-975X","authenticated-orcid":false,"given":"Sunil","family":"Golia","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine Goa Medical College and Hospital  Goa India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aseem Kumar","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Medanta\u2013The Medicity  Gurgaon India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6716-4889","authenticated-orcid":false,"given":"Samruddhi","family":"Pawar","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Medanta\u2013The Medicity  Gurgaon India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo M. G.","family":"van de Watering","sequence":"additional","affiliation":[{"name":"Sanquin Blood Supply Foundation Jon J van Rood Centre for Clinical Transfusion Research  The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,31]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Blood For Life.Blood Transfusion Services Directorate General of Health Services Ministry of Health and Family Welfare Government of India. Available from:https:\/\/eraktkosh.mohfw.gov.in\/BLDAHIMS\/bloodbank\/notification.cnt. Last accessed 28 Jan 2025."},{"key":"e_1_2_11_3_1","unstructured":"Screening donated blood for transfusion\u2010transmissible infections. Geneva World Health Organization; 2010.http:\/\/www.who.int\/bloodsafety\/publications\/bts_screendondbloodtransf\/en\/index.html. Last accessed 28 Jan 2025."},{"key":"e_1_2_11_4_1","unstructured":"Department of Health and Family Welfare Ministry of Health and Family Welfare Government of India.Gazette of India.https:\/\/cdsco.gov.in\/opencms\/opencms\/en\/Notifications\/Gazette\u2010Notifications. Last accessed 28 Jan 2025."},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.14260\/jemds\/2021\/186"},{"key":"e_1_2_11_6_1","first-page":"9","article-title":"Prevalence of major transfusion\u2010transmissible infections among blood donors at a rural tertiary healthcare teaching Hospital of North India","volume":"4","author":"Mahajan P","year":"2019","journal-title":"Saudi J Pathol Microbiol"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.14260\/jemds\/2019\/678"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.18231\/j.ijpo.2019.086"},{"key":"e_1_2_11_9_1","first-page":"87","article-title":"Transfusion transmissible infection \u2013 a 7\u2009years prospective study in RIMS hospital, Manipur","volume":"18","author":"Khoyumthem P","year":"2019","journal-title":"IOSR J Dent Med Sci"},{"key":"e_1_2_11_10_1","first-page":"L1","article-title":"Seroprevalence of transfusion transmissible infections among blood donors at a tertiary care teaching 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