{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T15:03:36Z","timestamp":1768489416415,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2026,1]]},"abstract":"Abstract<\/jats:title>\n \n Background and Objectives<\/jats:title>\n \n In July 2020, Brazil removed the long\u2010standing restrictions on blood donation by men who have sex with men\n (MSM)<\/jats:styled-content>\n , shifting donor eligibility criteria towards individual behavioural risk assessment. We sought to establish the impact of this policy change on the safety of the blood supply.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n This retrospective cross\u2010sectional study evaluated the prevalence and incidence of human immunodeficiency virus (\n HIV)<\/jats:styled-content>\n , hepatitis B virus (\n HBV)<\/jats:styled-content>\n , hepatitis C virus (\n HCV)<\/jats:styled-content>\n and syphilis among blood donors at Funda\u00e7\u00e3o Pr\u00f3\u2010Sangue\/Hemocentro de S\u00e3o Paulo. Data were analysed across two periods: before (\n P1<\/jats:styled-content>\n : January 2019\u2013June 2020) and after (\n P2<\/jats:styled-content>\n : July 2020\u2013December 2023) the\n MSM<\/jats:styled-content>\n policy change. Prevalence was assessed in first\u2010time donors, and incidence was calculated among repeat donors. The chi\u2010square testing was used for statistical comparisons (\n p<\/jats:italic>\n \u2009<\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 560,528 donations were included in the study. There were no significant differences in the prevalence per 100,000 donations of\n HIV<\/jats:styled-content>\n (46.3 vs. 43.5;\n p<\/jats:italic>\n \u2009=\u20090.77),\n HBV<\/jats:styled-content>\n (33.3 vs. 27.7;\n p<\/jats:italic>\n \u2009=\u20090.56) or\n HCV<\/jats:styled-content>\n (94.1 vs. 72.6;\n p<\/jats:italic>\n \u2009=\u20090.09) markers between\n P1<\/jats:styled-content>\n and\n P2<\/jats:styled-content>\n . However, the prevalence of serological markers for syphilis increased significantly (745.7 vs. 1115.8;\n p<\/jats:italic>\n \u2009<\u20090.0001) after the policy change. Donors with positive serological markers for syphilis in\n P2<\/jats:styled-content>\n were mostly younger and had higher education levels.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Lifting the\n MSM<\/jats:styled-content>\n deferral policy in Brazil did not increase the prevalence or incidence of\n HIV<\/jats:styled-content>\n ,\n HBV<\/jats:styled-content>\n or\n HCV<\/jats:styled-content>\n markers among blood donors. The observed increase in the prevalence of serological markers for syphilis likely reflects broader population trends. These findings support risk\u2010based donor screening as a safe and equitable approach to blood collection.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/vox.70130","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:58:32Z","timestamp":1760489912000},"page":"64-72","source":"Crossref","is-referenced-by-count":0,"title":["Assessing the effect of policy change on transfusion safety in Brazil: A three\u2010and\u2010a\u2010half\u2010year study after lifting the deferral for men who have sex with men"],"prefix":"10.1111","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0623-1999","authenticated-orcid":false,"given":"Anna","family":"Nishiya","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Pr\u00f3\u2010Sangue Hemocentro de S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Oncoimmunohematology (LIM\u201031), Department of Hematology, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4190-0238","authenticated-orcid":false,"given":"Suzete","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Pr\u00f3\u2010Sangue Hemocentro de S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Oncoimmunohematology (LIM\u201031), Department of Hematology, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8490-4634","authenticated-orcid":false,"given":"Cesar","family":"de Almeida\u2010Neto","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Pr\u00f3\u2010Sangue Hemocentro de S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Disciplina de Ci\u00eancias M\u00e9dicas Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP) S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caio","family":"Almeida","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Pr\u00f3\u2010Sangue Hemocentro de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanci","family":"Salles","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Pr\u00f3\u2010Sangue Hemocentro de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanderson","family":"Rocha","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Pr\u00f3\u2010Sangue Hemocentro de S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Oncoimmunohematology (LIM\u201031), Department of Hematology, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Disciplina de Ci\u00eancias M\u00e9dicas Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP) S\u00e3o Paulo Brazil"},{"name":"Churchill Hospital, Oxford University Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Mendrone\u2010Junior","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Pr\u00f3\u2010Sangue Hemocentro de S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Oncoimmunohematology (LIM\u201031), Department of Hematology, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"BRASIL.Lei n\u00b0 7.649 de 25 de janeiro de 1988. Estabelece a obrigatoriedade do cadastramento dos doadores de sangue bem como a realiza\u00e7\u00e3o de exames laboratoriais no sangue coletado visando a prevenir a propaga\u00e7\u00e3o de doen\u00e7as e d\u00e1 outras provid\u00eancias. Di\u00e1rio Oficial da Uni\u00e3o: se\u00e7\u00e3o 1 Bras\u00edlia DF 25 Jan 1988. Available from:https:\/\/www.planalto.gov.br\/ccivil_03\/leis\/1980-1988\/l7649.htm. Last accessed 1 Jul 2025."},{"key":"e_1_2_9_3_1","unstructured":"BRASIL. Minist\u00e9rio da Sa\u00fade.Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria. Resolu\u00e7\u00e3o RDC n\u00b0 153 de 14 de junho de 2004. Estabelece requisitos t\u00e9cnicos e sanit\u00e1rios para a doa\u00e7\u00e3o de sangue e hemocomponentes. Di\u00e1rio Oficial da Uni\u00e3o: se\u00e7\u00e3o 1 Bras\u00edlia DF 14 Jun 2004. Available from:https:\/\/bvsms.saude.gov.br\/bvs\/saudelegis\/anvisa\/2004\/rdc0153_14_06_2004.html. Last accessed 1 Jul 2025."},{"key":"e_1_2_9_4_1","unstructured":"BRASIL. Minist\u00e9rio da Sa\u00fade.Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria. Resolu\u00e7\u00e3o RDC n\u00b0 34 de 11 de junho de 2014. Disp\u00f5e sobre os requisitos t\u00e9cnicos e sanit\u00e1rios para doa\u00e7\u00e3o de sangue e hemocomponentes. Di\u00e1rio Oficial da Uni\u00e3o: se\u00e7\u00e3o 1 Bras\u00edlia DF 11 Jun 2014. Available from:https:\/\/bvsms.saude.gov.br\/bvs\/saudelegis\/anvisa\/2014\/rdc0034_11_06_2014.pdf. Last accessed 1 Jul 2025."},{"key":"e_1_2_9_5_1","unstructured":"BRASIL. Minist\u00e9rio da Sa\u00fade.Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria. Resolu\u00e7\u00e3o RDC n\u00b0 399 de 7 de julho de 2020. Disp\u00f5e sobre a regulamenta\u00e7\u00e3o do deferimento tempor\u00e1rio para doa\u00e7\u00e3o de sangue e outras disposi\u00e7\u00f5es. Di\u00e1rio Oficial da Uni\u00e3o: se\u00e7\u00e3o 1 Bras\u00edlia DF 8 Jul 2020. Available from:https:\/\/bvsms.saude.gov.br\/bvs\/saudelegis\/anvisa\/2020\/rdc0399_7_07_2020.pdf. 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