{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T17:01:51Z","timestamp":1781110911306,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>The number of critically ill patients with haematological conditions is increasing, yet transfusion practices in this population remain poorly defined. This study aimed to compare transfusion strategies in critically ill patients with versus without haematological conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>This international, prospective observational substudy of the International Point Prevalence Study of Intensive Care Unit [ICU] Transfusion Practices (InPUT) evaluated transfusion use in ICU patients with and without haematological conditions, including benign or malignant diseases or a history of stem cell transplantation. Outcomes included use of red blood cells (RBCs), platelets, plasma, haemostatic interventions, transfusion indications and thresholds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 3643 ICU patients, 131 (3.6%) had a haematological condition. These patients were more likely to receive RBC (odds ratio [OR] 1.58, 95% confidence interval [CI] 1.09\u20132.29) and platelet transfusions (OR 8.32, 95% CI 5.09\u201313.6), primarily due to low haemoglobin rather than physiological triggers. Platelet thresholds were lower (median 23\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L vs. 64\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L) compared to non\u2010haematology patients. Both platelet and plasma transfusions were more frequently administered prophylactically rather than for active bleeding. Haemostatic interventions were more often used in haematology patients, at higher doses and typically without viscoelastic testing. Transfused haematology patients had higher 28\u2010day mortality and longer ICU stays.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ICU patients with haematological conditions receive transfusions differently, particularly regarding platelet and plasma use. These findings underscore the need for prospective studies to define optimal transfusion thresholds in this growing and vulnerable patient population, although the study's limited sample size and lack of diagnostic granularity may affect interpretation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.70153","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T02:19:37Z","timestamp":1764037177000},"page":"169-179","source":"Crossref","is-referenced-by-count":2,"title":["Multinational transfusion practices and outcomes in haematology patients admitted to the intensive care unit"],"prefix":"10.1111","volume":"121","author":[{"given":"Caroline M.","family":"Schaap","sequence":"first","affiliation":[{"name":"Department of Intensive Care Amsterdam University Medical Centers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3634-5129","authenticated-orcid":false,"given":"Laurens A.","family":"Oomen","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Amsterdam University Medical Centers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senta Jorinde","family":"Raasveld","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Amsterdam University Medical Centers  Amsterdam The Netherlands"},{"name":"Department of Anesthesiology Amsterdam University Medical Centers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy","family":"Schenk","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Amsterdam University Medical Centers  Amsterdam The Netherlands"},{"name":"Department of Anesthesiology Amsterdam University Medical Centers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanne","family":"de Bruin","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Amsterdam University Medical Centers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3738-0397","authenticated-orcid":false,"given":"Merijn C.","family":"Reuland","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Amsterdam University Medical Centers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"van den Oord","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Amsterdam University Medical Centers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Bakker","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Adults Erasmus MC University Medical Centers  Rotterdam The Netherlands"},{"name":"Department of Intensive Care Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Cecconi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care IRCCS Humanitas Research Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarne","family":"Feldheiser","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, EvangKliniken Essen\u2010Mitte Huyssens\u2010Stiftung\/Knappschaft  Essen Germany"},{"name":"Department of Anesthesiology, Intensive Care Medicine, and Pain Therapy University Hospital Knappschaftskrankenhaus Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Meier","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Kepler University Clinic  Linz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"McQuilten","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W. L.","family":"Scheeren","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7808-3606","authenticated-orcid":false,"given":"C\u00e9cile","family":"Aubron","sequence":"additional","affiliation":[{"name":"M\u00e9decine Intensive R\u00e9animation, CHU de Brest Universit\u00e9 de Bretagne Occidentale  Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew W. J.","family":"Flint","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Australia"},{"name":"The Australian and New Zealand Intensive Care Research Centre (ANZIC\u2010RC), School of Public Health and Preventive Medicine Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarikul","family":"Hamid","sequence":"additional","affiliation":[{"name":"Department of Critical Care Asgar Ali Hospital  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u00ebl","family":"Piagnerelli","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, CHU Charleroi Marie Curie Universit\u00e9 Libre de Brussels  Charleroi Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina Tomi\u0107","family":"Mahe\u010di\u0107","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive 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General Monte Sina\u00ed  Cuenca Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantina","family":"Triantafyllopoulou","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery European Interbalkan Medical Center  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliki","family":"Chantziara","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, First Department of Respiratory Medicine National and Kapodistrian University of Athens, Sotiria Chest Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8489-0324","authenticated-orcid":false,"given":"Mohan","family":"Gurjar","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila 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