{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:37:16Z","timestamp":1784871436976,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>The Vel antigen is clinically significant and its alloantibody is involved in haemolytic transfusion reactions. This antigen has a high prevalence in the population. The Vel\u2010negative phenotype is the result of a homozygous deletion in the SMIM1 gene (c.64_80del) and hinders the expression of the SMIM1 protein.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A total of 17,472 blood donor samples from the Center for Hematology and Hemotherapy of Santa Catarina State were genotyped targeting the 17\u2010nucleotide (c.64_80del) deletion in the SMIM1 gene. The same method was applied to the siblings of the donors identified as Vel\u2010negative.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The frequency of the c.64_80del17 deletion was 0.90%, and 0.03% of the donors were Vel\u2010negative. In the family study, two individuals were identified as having the homozygous c.64_80del.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings underscore the relevance of identifying Vel\u2010negative donors for enhancing rare donor registries and improving transfusion safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.70187","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:37:53Z","timestamp":1771202273000},"page":"384-389","source":"Crossref","is-referenced-by-count":1,"title":["Molecular identification of Vel\u2010negative blood donors in a population from southern Brazil"],"prefix":"10.1111","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3946-2659","authenticated-orcid":false,"given":"D.","family":"Siegel","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Biology, Microbiology and Serology Federal University of Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"},{"name":"Santa Catarina Hematology and Hemotherapy Center  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. J.","family":"Sch\u00f6rner","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Microbiology and Serology Federal University of Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"},{"name":"Santa Catarina Hematology and Hemotherapy Center  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7303-6050","authenticated-orcid":false,"given":"M. A.","family":"Sch\u00f6rner","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Microbiology and Serology Federal University of Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Grisard","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Microbiology and Serology Federal University of Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6409-3021","authenticated-orcid":false,"given":"F. H.","family":"Barazzetti","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Microbiology and Serology Federal University of Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Kupek","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Microbiology and Serology Federal University of Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Bazzo","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Microbiology and Serology Federal University of Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00565.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201302466"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2600"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parepi.2019.e00101"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16169"},{"key":"e_1_2_8_7_1","first-page":"60","article-title":"SMIM1 polymorphisms in a donor population from Southeast Brazil and their correlation with VEL expression","volume":"17","author":"Arnoni CP","year":"2019","journal-title":"Blood Transfus"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2019.03.006"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2603"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13014"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000440791"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep40451"},{"key":"e_1_2_8_13_1","unstructured":"Brazilian Institute of Geography and Statistics (IBGE).2022 Brazilian Demographic Census.2022. Available from:https:\/\/www.ibge.gov.br\/estatisticas\/sociais\/trabalho\/22827-censo-demografico-2022.html. Last accessed 25 Jan 2024."},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15059"},{"key":"e_1_2_8_15_1","volume-title":"Investigation of blood group gene polymorphisms in voluntary blood donors and patients with hemopathies in the state of Santa Catarina","author":"Costa DC","year":"2016"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.70187","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.70187","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.70187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T02:07:33Z","timestamp":1773367653000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.70187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,15]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/vox.70187"],"URL":"https:\/\/doi.org\/10.1111\/vox.70187","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,15]]}}}