{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:14:20Z","timestamp":1789038860014,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>High\u2010sensitivity assays for infectious screening of blood donations still occasionally result in false\u2010positive test results (FPTRs). The cause of FPTRs is not always clear and may stem from both lot\u2010dependent and lot\u2010independent factors. FPTRs generate additional administration and extra costs for confirmatory testing and may cause concern among deferred donors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      First\u2010time and second\u2010time FPTRs among blood donors screened from January 2021 to November 2023 were identified in the blood bank computer system. Abbott Alinity\n                      <jats:italic>i<\/jats:italic>\n                      hepatitis B surface antigen, hepatitis C virus (HCV) antibody and human immunodeficiency virus (HIV) antibody\/antigen\u00a0assays and Roche Cobas MPX assay were used for screening. Using logistic regression, we examined whether the risk of second\u2010time FPTR was affected by being a new donor, sex, age and time between two donations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the study period, 38,962 donors gave 223,323 donations. The total number of FPTRs was 216. Among the donors with a first\u2010time FPTR, 83 had a second donation within the observation period, and 56 (67.5%) of these had a second\u2010time FPTR. In total, 0.2% of donors were deferred because of second\u2010time FPTR. New donors with a first\u2010time FPTR had a significantly higher risk (adjusted odds ratio [aOR]\u2009=\u20096.06, 95% confidence interval [CI] [1.17\u201331.55]) of a second\u2010time FPTR, which occurred in 89.5% of cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>An increased risk of second\u2010time FPTR was found among new donors, and hence it may be beneficial considering the donors\u2032 ethical and economical aspects, to defer this group of donors after the initial FPTR. Lot\u2010independent factors might explain why some donors keep getting FPTR even after years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.70191","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T01:26:50Z","timestamp":1770773210000},"page":"281-288","source":"Crossref","is-referenced-by-count":1,"title":["False\u2010positive infectious screening results among blood donors"],"prefix":"10.1111","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4795-3508","authenticated-orcid":false,"given":"Sofie Dolores Holm","family":"M\u00fcller","sequence":"first","affiliation":[{"name":"Clinical Immunology Research Unit, Department of Clinical Immunology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mie Topholm","family":"Bruun","sequence":"additional","affiliation":[{"name":"Clinical Immunology Research Unit, Department of Clinical Immunology Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen","family":"Georgsen","sequence":"additional","affiliation":[{"name":"Clinical Immunology Research Unit, Department of Clinical Immunology Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorte K.","family":"Holm","sequence":"additional","affiliation":[{"name":"Clinical Immunology Research Unit, Department of Clinical Immunology Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s44313-024-00014-w"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02110.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00352-18"},{"key":"e_1_2_9_5_1","unstructured":"Bekendtg\u00f8relse om sikkerhed i forbindelse med bloddonation (BEK nr. 818 af 25\/06\/2024).2024. 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