{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:14:03Z","timestamp":1778894043376,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008627","name":"Global Affairs Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008627","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Patients with haematological malignancies often require blood transfusion support. Multiple allogeneic blood transfusions may result in alloimmunization, complicating future transfusions. This study determined alloantibody prevalence, specificities and factors associated with the presence of red blood cell (RBC) alloantibodies among transfused patients with haematological malignancies at Mbarara Regional Referral Hospital (MRRH) and the Uganda Cancer Institute (UCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This was a cross\u2010sectional study among patients with haematological malignancies who had been multiply transfused and were seeking cancer care at MRRH and the UCI, in Uganda. Patient plasma was screened for the presence of RBC alloantibodies using haemagglutination testing with a 3\u2010cell commercial reagent RBC and antibody identification with 11\u2010cell antibody panels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 427 patients with a median age of 36 (inter\u2010quartile range: 26\u201356\u2009years) were investigated. Twenty\u2010five participants (5.9%) possessed RBC alloantibodies whose specificities were as follows: anti\u2010C, two; anti\u2010D, four; anti\u2010E, six; anti\u2010K, four; and anti\u2010c, anti\u2010Fy\n                      <jats:sup>a<\/jats:sup>\n                      , anti\u2010Jk\n                      <jats:sup>a<\/jats:sup>\n                      , anti\u2010Le\n                      <jats:sup>a<\/jats:sup>\n                      and anti\u2010M, one each. Four patients possessed pan\u2010reactive antibodies. Patients with chronic cancer (adjusted odds ratio [AOR]\u2009=\u20092.62, 95% confidence interval [CI]: 1.16\u20137.21), leukaemia (AOR\u2009=\u20092.71, 95% CI: 1.81\u20134.03), human immunodeficiency virus (HIV) infection (AOR\u2009=\u20094.34, 95% CI: 1.69\u20135.11), antibiotic use (AOR\u2009=\u20095.08, 95% CI: 2.11\u20137.41) and a history of \u22655 transfusions were significantly associated with RBC alloimmunization (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RBC alloimmunization prevalence was 5.9% and associated with clinical and transfusion\u2010related factors. Alloantibodies to Rh, Kell, MNS, Duffy, Kidd and Lewis blood group systems were detected, underscoring the need for improved pre\u2010transfusion testing in Uganda.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.70198","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T01:29:59Z","timestamp":1770773399000},"page":"614-624","source":"Crossref","is-referenced-by-count":2,"title":["Red blood cell alloantibodies in transfused patients with haematological malignancies at Mbarara Regional Referral Hospital and the Uganda Cancer Institute: Prevalence, specificities and associated factors"],"prefix":"10.1111","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1048-1405","authenticated-orcid":false,"given":"Ivan Mugisha","family":"Taremwa","sequence":"first","affiliation":[{"name":"Faculty of Medicine Mbarara University of Science and Technology  Mbarara Uganda"},{"name":"Institute of Allied Health Sciences Clarke International 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Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benson","family":"Okongo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Mbarara University of Science and Technology  Mbarara Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Nambozi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Mbarara University of Science and Technology  Mbarara Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"May Y.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Snyder Institute for Chronic Diseases University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig N.","family":"Jenne","sequence":"additional","affiliation":[{"name":"Snyder Institute for Chronic Diseases University of Calgary  Calgary Alberta 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