{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:36:40Z","timestamp":1792676200625,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Pathogen reduction (PR) using amotosalen\u2010UVA was implemented for 100% of platelet concentrates (PCs) in France in November 2017. No bacterial testing was in place earlier. The impact of PR on the risk of transfusion\u2010transmitted infections (TTIs) from November 2017 to December 2022 (vs. January 2013 to October 2017) has been published previously. To further assess the impact of PR implementation, the evaluation period was expanded to December 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>PC\u2010associated TTIs occurring in 2023 and 2024 were analysed and included in the assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two cases of PC\u2010associated transfusion\u2010transmitted bacterial infections (TTBIs) were reported. The first involved\n                      <jats:italic>Bacillus mobilis<\/jats:italic>\n                      in a split pooled whole blood\u2013derived PC. This Grade 2 TTBI was diagnosed following identification of the same pathogen in the second PC unit, quarantined for failed swirling test. The second involved\n                      <jats:italic>Staphylococcus ureilyticus<\/jats:italic>\n                      in an apheresis PC transfused to a patient who subsequently died. TTBI frequency decreased from 1\/97,098 PC (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915 over 5\u2009years, 2 deaths) to 1\/787,662 PC (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093, over 7\u2009years, 1 death) after PR implementation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). No human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), human T\u2010cell lymphotropic virus (HTLV) or arboviruses TTI were reported from 2013 to 2024. No further cases of PC\u2010associated hepatitis E virus (HEV) TTI were reported, concomitantly to HEV\u2010nucleic acid testing implementation. A PC\u2010associated parvovirus B19 TTI occurred in 2024. The use of PR PCs facilitated PC supply during arboviral outbreaks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The reduction in PC\u2010related TTBIs following PR implementation is confirmed. However, the recent occurrence of two severe TTBI cases highlights a persistent risk. Prevention of PR\u2010PC\u2010associated TTIs by non\u2010enveloped viruses requires specific screening.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.70199","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T02:06:19Z","timestamp":1771380379000},"page":"581-586","source":"Crossref","is-referenced-by-count":4,"title":["Pathogen\u2010reduced platelet concentrates in France: Impact on the risk of transfusion\u2010transmitted infections, 2017\u20132024"],"prefix":"10.1111","volume":"121","author":[{"given":"Syria","family":"Laperche","sequence":"first","affiliation":[{"name":"\u00c9tablissement Fran\u00e7ais du Sang  La Plaine Saint\u2010Denis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"de la Taille","sequence":"additional","affiliation":[{"name":"\u00c9tablissement Fran\u00e7ais du Sang  La Plaine Saint\u2010Denis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Gallian","sequence":"additional","affiliation":[{"name":"\u00c9tablissement Fran\u00e7ais du Sang  La Plaine Saint\u2010Denis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Pouchol","sequence":"additional","affiliation":[{"name":"\u00c9tablissement Fran\u00e7ais du Sang  La Plaine Saint\u2010Denis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Humbrecht","sequence":"additional","affiliation":[{"name":"\u00c9tablissement Fran\u00e7ais du Sang  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Montembault","sequence":"additional","affiliation":[{"name":"Etablissement Fran\u00e7ais du Sang  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucile","family":"Malard","sequence":"additional","affiliation":[{"name":"\u00c9tablissement Fran\u00e7ais du Sang  La Plaine Saint\u2010Denis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Bacquet","sequence":"additional","affiliation":[{"name":"\u00c9tablissement Fran\u00e7ais du Sang  La Plaine Saint\u2010Denis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Asso\u2010Bonnet","sequence":"additional","affiliation":[{"name":"\u00c9tablissement Fran\u00e7ais du Sang  La Plaine Saint\u2010Denis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3322-3580","authenticated-orcid":false,"given":"Sophie","family":"Le Cam","sequence":"additional","affiliation":[{"name":"\u00c9tablissement Fran\u00e7ais du Sang  La Plaine Saint\u2010Denis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7715-568X","authenticated-orcid":false,"given":"Thierry","family":"Peyrard","sequence":"additional","affiliation":[{"name":"\u00c9tablissement Fran\u00e7ais du Sang  La Plaine Saint\u2010Denis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9310-8322","authenticated-orcid":false,"given":"Pierre","family":"Tiberghien","sequence":"additional","affiliation":[{"name":"\u00c9tablissement Fran\u00e7ais du Sang  La Plaine Saint\u2010Denis France"},{"name":"UMR RIGHT 1098, Universit\u00e9 Marie et Louis Pasteur, INSERM Etablissement Fran\u00e7ais du Sang  Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2012.01662.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13171"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms12020258"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13574"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.70053"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2024.29.21.2400253"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2910.230869"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13272"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.2000.7840209.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/msphere.00673-22"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16210"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.04125.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10020170"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.925866"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00109-13"},{"key":"e_1_2_9_17_1","unstructured":"SHOT report 2024. Transfusion\u2010transmitted infections. Available from:https:\/\/www.shotuk.org\/wp-content\/uploads\/2025\/07\/23.-Transfusion-Transmitted-Infections-TTI-2024.pdf. Last accessed 31 Jul 2025."},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13375"},{"key":"e_1_2_9_19_1","first-page":"110","article-title":"Seven years (2015\u20102021) of blood donor screening for HEV\u2010RNA in France: lessons and perspectives","volume":"21","author":"Laperche S","year":"2023","journal-title":"Blood Transfus"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445195"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.70199","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.70199","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.70199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:47:44Z","timestamp":1778892464000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.70199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,17]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/vox.70199"],"URL":"https:\/\/doi.org\/10.1111\/vox.70199","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,17]]}}}