{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:05:48Z","timestamp":1792253148490,"version":"4.4.0"},"reference-count":60,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Cytomegalovirus (CMV) causes harm in at\u2010risk populations. Selection of seronegative donors has been used to prevent transmission. Leucodepletion reduces the potential for CMV transmission; however, the residual risk is uncertain, leading to variability in practice. This study systematically reviews the risk of CMV transmission in leucodepleted blood products compared to seronegative blood products.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A systematic review identified comparative studies of CMV infection rates following transfusion of leucodepleted blood from CMV\u2010negative or unselected donors. Preclinical studies on blood product CMV transmission, reported cases and studies that informed population risk were also reviewed. Meta\u2010analysis was performed on comparative studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was no difference in the rate of infection following transfusion of leucodepleted cellular products with or without donor CMV seronegativity selection, with a relative risk of 1.21 (95% confidence interval [CI]: 0.42\u20133.49). No confirmed cases of CMV transmission were found. Preclinical studies showed a significant reduction in transmissible virus with leucodepletion, although no threshold could be defined. Cell\u2010free CMV is not removed by filtration, and although it may remain a potential source of infection, there was no evidence of transmission through plasma, possibly due to detectable virus not reflecting intact transmissible virus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Selecting CMV\u2010seronegative donors did not reduce the risk of transmission when transfusing leucodepleted blood products because of the high efficiency of filters in removing transmissible cellular virus. This finding suggests CMV donor negative selection does not substantially contribute to donor safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.70219","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T02:09:38Z","timestamp":1771380578000},"page":"722-731","source":"Crossref","is-referenced-by-count":5,"title":["Serological screening for cytomegalovirus in a leucodepleted blood supply: A systematic review"],"prefix":"10.1111","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4124-4971","authenticated-orcid":false,"given":"Philip J.","family":"Crispin","sequence":"first","affiliation":[{"name":"Australian and New Zealand Society of Blood Transfusion Clinical Transfusion Practice Committee  Sydney New South Wales Australia"},{"name":"Australian National University School of Medicine and Psychology  Canberra Australian Capital Territory Australia"},{"name":"Haematology Department Canberra Hospital  Garran Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Edwards","sequence":"additional","affiliation":[{"name":"Hunter New England Local Health District  Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Beattie","sequence":"additional","affiliation":[{"name":"Australian and New Zealand Society of Blood Transfusion Clinical Transfusion Practice Committee  Sydney New South Wales Australia"},{"name":"Western New South Wales Local Health District  Orange New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Brown","sequence":"additional","affiliation":[{"name":"Australian and New Zealand Society of Blood Transfusion Clinical Transfusion Practice Committee  Sydney New South Wales Australia"},{"name":"Murrumbidgee Local Health District  Wagga Wagga New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Clarke","sequence":"additional","affiliation":[{"name":"Australian and New Zealand Society of Blood Transfusion Clinical Transfusion Practice Committee  Sydney New South Wales Australia"},{"name":"Australian Red Cross Lifeblood  Sydney New South Wales Australia"},{"name":"Sydney Adventist Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"King","sequence":"additional","affiliation":[{"name":"Australian and New Zealand Society of Blood Transfusion Clinical Transfusion Practice Committee  Sydney New South Wales Australia"},{"name":"New Zealand Blood Service  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Ormerod","sequence":"additional","affiliation":[{"name":"Australian and New Zealand Society of Blood Transfusion Clinical Transfusion Practice Committee  Sydney New South Wales Australia"},{"name":"La Trobe Regional Health  Traralgon Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5219-9176","authenticated-orcid":false,"given":"Bryony","family":"Ross","sequence":"additional","affiliation":[{"name":"Australian and New Zealand Society of Blood Transfusion Clinical Transfusion Practice Committee  Sydney New South Wales Australia"},{"name":"John Hunter Children's Hospital  Newcastle New South Wales Australia"},{"name":"School of Medicine &amp; 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