{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:26:21Z","timestamp":1787671581014,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Accurate detection of transfusion\u2010transmissible infections, such as human immunodeficiency virus (HIV) and hepatitis C and B viruses (HCV\/HBV), is critical to ensure blood safety, and screening assays must demonstrate high specificity and sensitivity. In this study, we compared the performances of Elecsys\u00ae HIV Duo, HCV Duo, Anti\u2010HCV II and HBsAg II immunoassays with those of comparator assays HIV Ag\/Ab Combo, Anti\u2010HCV II and HBsAg on the Alinity\u00ae s platform and HIV Ag\/Ab Combo, Anti\u2010HCV and HBsAg Qualitative II on the Alinity i platform.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Approximately 2050 plasma samples from first\u2010time blood donors and commercial seroconversion panels were used. Specificity was assessed as the proportion of true non\u2010reactive samples identified by each assay. Seroconversion sensitivity was evaluated based on the detection time and average interval from nucleic acid testing (NAT)\u2010positivity to assay reactivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, all Elecsys assays evaluated had similar specificities as the corresponding Alinity s\/i assays, although the absolute difference in specificity between Alinity i Anti\u2010HCV assay and the other HCV assays was statistically significant. The seroconversion sensitivities of Elecsys HIV Duo and HBsAg II assays were similar to the corresponding Alinity s\/i assays. For HCV, Elecsys HCV Duo assay detected infection earlier than Alinity s\/i assays for most panels (87.0% and 91.8%, respectively), with an average detection time from NAT positivity for HCV RNA of 1.5\u2009days versus 21.4 and 23.8\u2009days, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The robust specificities and early detection capabilities of the evaluated Elecsys assays support their routine use in blood donor screening and diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.70222","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T02:09:37Z","timestamp":1771380577000},"page":"814-821","source":"Crossref","is-referenced-by-count":2,"title":["Comparing specificity and seroconversion sensitivity among major blood screening assays for human immunodeficiency virus and viral hepatitis"],"prefix":"10.1111","volume":"121","author":[{"given":"Monica","family":"Chaves","sequence":"first","affiliation":[{"name":"Roche Diagnostics International  Rotkreuz Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Schaetzl","sequence":"additional","affiliation":[{"name":"Roche Diagnostics GmbH  Penzberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2677-2722","authenticated-orcid":false,"given":"Florina","family":"Pessl","sequence":"additional","affiliation":[{"name":"Roche Diagnostics GmbH  Penzberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization.Global health sector strategies on respectively HIV viral hepatitis and sexually transmitted infections for the period 2022\u20132030. Available from:https:\/\/www.who.int\/teams\/global-hiv-hepatitis-and-stis-programmes\/strategies\/global-health-sector-strategies. Last accessed 11 Nov 2025."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-0332-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)01449-7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(24)00212-1"},{"key":"e_1_2_9_6_1","unstructured":"World Health Organization.Guidelines for the prevention diagnosis care and treatment for people with chronic hepatitis B infection. Available from:https:\/\/www.who.int\/publications\/i\/item\/9789240090903. Last accessed 11 Nov 2025."},{"key":"e_1_2_9_7_1","unstructured":"World Health Organization.Hepatitis C \u2013 fact sheet. Available from:https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hepatitis-c. Last accessed 11 Nov 2025."},{"key":"e_1_2_9_8_1","unstructured":"World Health Organization.Consolidated guidelines on HIV prevention testing treatment service delivery and monitoring: recommendations for a public health approach. Available from:https:\/\/www.who.int\/publications\/i\/item\/9789240031593. Last accessed 11 Nov 2025."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr6902a1"},{"key":"e_1_2_9_10_1","unstructured":"Centers for Disease Control and Prevention.Clinical testing and diagnosis for hepatitis B. Available from:https:\/\/www.cdc.gov\/hepatitis-b\/hcp\/diagnosis-testing\/index.html. Last accessed 11 Nov 2025."},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad319"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2021.06.005"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlife.2024.06.001"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/covid4080091"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s44174-024-00169-1"},{"key":"e_1_2_9_16_1","unstructured":"Abbott.Alinity s Anti\u2010HCV II reagent kit. Package insert. Available from:https:\/\/www.fda.gov\/media\/159972\/download. Last accessed 11 Nov 2025."},{"key":"e_1_2_9_17_1","unstructured":"Abbott.Alinity ci\u2010series. Available from:https:\/\/www.corelaboratory.abbott\/int\/en\/offerings\/brands\/alinity\/alinity-ci-series.html. Last accessed 11 Nov 2025."},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12908"},{"key":"e_1_2_9_19_1","unstructured":"European Parliament.Directive 98\/79\/EC of the European Parliament and of the Council of 27 October 1998 on in vitro diagnostic medical devices. Available from: Directive\u201098\/79\u2010EN\u2010EUR\u2010Lex. Last accessed 11 Nov 2025."},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12259"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23536"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2022.105293"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2018.11.005"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-007-0059-9"},{"key":"e_1_2_9_25_1","first-page":"335","article-title":"P338: Performance evaluation of a new HCV Ag\/Ab combination assay at the Western Cape Blood Service, Cape Town, South Africa. 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Supplement: Abstracts of the 38th International Congress of the ISBT, Barcelona, Spain, 23\u201327 June 2024","volume":"119","author":"Bar\u00f3thi\u2010T\u00f3th K","year":"2024","journal-title":"Vox Sang"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2012.06.012"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2009.01272.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25845"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.70222","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.70222","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.70222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:22:51Z","timestamp":1781137371000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.70222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,17]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/vox.70222"],"URL":"https:\/\/doi.org\/10.1111\/vox.70222","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,17]]}}}