{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T01:01:04Z","timestamp":1781139664669,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100001023","name":"Amon G. Carter Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001023","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Transfusion\u2010associated circulatory overload (TACO) is the leading cause of transfusion\u2010related morbidity and mortality. We evaluated the incidence of TACO and its association with new fever (HOT\u2010TACO) at a comprehensive cancer centre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Retrospective review of haemovigilance data (July 2019\u2013October 2020) identified 100 possible to definite TACO cases. TACO cases were classified as HOT\u2010TACO or regular TACO, differentiated by an association with new\u2010onset fever. Both groups were assessed by type, age of blood products involved, reaction severity, cancer diagnosis and white blood cells (WBC) counts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 1382 transfusion reactions in a 15\u2010month period, 111 cases of TACO (8%) were diagnosed. A total of 100 adult TACO cases were included in this study; 16% of them were HOT\u2010TACO cases. The median WBC counts pre\u2010 and post\u2010transfusion in the HOT\u2010TACO versus regular\u2010TACO group were not statistically different (pre\u2010 5.400 vs. 2.050,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.19; post 4.100 vs. 1.900,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.45). However, the HOT\u2010TACO group had a 2.7\u2010fold higher pre\u2010WBC and a 2.2\u2010fold higher post\u2010WBC when compared with the regular TACO group. There were no significant differences in age of the blood products involved, red blood cell (RBC) age (median 12\u2009days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.34), platelet age (single donor platelet [SDP]\/random donor platelet [RDP] unit) (median 5\/5\u2009days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.32\/\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.72) or reaction severity between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found an association of TACO and new fever in 16% of cases compared with 32% reported in a non\u2010exclusive oncological setting. Findings are likely related to impaired immune response present in cancer patients associated with immunosuppression. Our findings support that fever should not be used to distinguish transfusion\u2010related acute lung injury (TRALI) from TACO.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.70237","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:14:17Z","timestamp":1773796457000},"page":"835-841","source":"Crossref","is-referenced-by-count":0,"title":["Febrile transfusion\u2010associated circulatory overload in adult oncology patients"],"prefix":"10.1111","volume":"121","author":[{"given":"Mayrin Correa","family":"Medina","sequence":"first","affiliation":[{"name":"Division of Pathology and Laboratory Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"},{"name":"Division of Pathology and Laboratory Medicine Moffitt Cancer Center  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5563-8018","authenticated-orcid":false,"given":"Marisol","family":"Maldonado","sequence":"additional","affiliation":[{"name":"Division of Pathology and Laboratory Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Bassett","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Martinez","sequence":"additional","affiliation":[{"name":"Division of Pathology and Laboratory Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"},{"name":"Department of Pathology and Laboratory Medicine University of Miami, Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Klein","sequence":"additional","affiliation":[{"name":"Division of Pathology and Laboratory Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0400-5138","authenticated-orcid":false,"given":"Colleen E.","family":"Villamin","sequence":"additional","affiliation":[{"name":"Division of Pathology and Laboratory Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Knopfelmacher","sequence":"additional","affiliation":[{"name":"Division of Pathology and Laboratory Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Gonta","sequence":"additional","affiliation":[{"name":"Division of Pathology and Laboratory Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"},{"name":"Division of Pathology and Laboratory Medicine Moffitt Cancer Center  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Kelley","sequence":"additional","affiliation":[{"name":"Division of Pathology and Laboratory Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"},{"name":"Pictor Labs  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(19)30080-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12466"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2012.08.019"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03247.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16882"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/lmab119"},{"key":"e_1_2_9_8_1","unstructured":"Fatalities reported to FDA following blood collection and transfusion annual summary for FY2022. 2022. 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