{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:19:23Z","timestamp":1792174763411,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Globally, there is high variability in paediatric transfusion practices. As per the World Health Organization (WHO), the majority of transfusions in low\u2010income countries are administered to children under 5\u2009years. This study aimed to characterize the epidemiology and indications for blood component transfusions among neonatal and paediatric patients across India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A prospective longitudinal multicentre study was conducted over 6\u2009months (April\u2013September 2022). Standardized data sheets captured age, gender, diagnosis, transfusion indication, component type and first versus repeat transfusion status for all paediatric requests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010three medical institutions (combined 32,759 beds) participated in the study. Among 396,092 total blood component requests, 52,658 (13.2%) were for paediatric patients. Most were male (60.1%), aged 5\u201312\u2009years (26.4%), and 42.7% required &gt;1 transfusion. Red cell components were the most frequently requested (68%), followed by platelets (17.5%) and plasma (12.3%). Medical indications accounted for 67.6% requests, followed by 30.3% surgical indications. Haematology (48%), oncology (17.1%) and infections (10.5%) were the most common medical indications; however, cardiac surgeries (44.2%) and gastrointestinal surgeries (30%) were the most common surgical indications. Haemoglobinopathies (21.4%) were overall the most common indication for the transfusions reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Paediatric patients accounted for over 13% of all transfusion requests, predominantly for red cells and medical indications (mainly haemoglobinopathy). This represents the first large\u2010scale epidemiological assessment of paediatric transfusion indications in India and establishes foundational evidence to guide understanding of blood utilization trends in children as well as indicate priority research areas for the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.70240","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:00:36Z","timestamp":1773277236000},"page":"848-860","source":"Crossref","is-referenced-by-count":3,"title":["Indication of transfusion of blood components in paediatric and neonatal patients in India: Real\u2010world multicentre data"],"prefix":"10.1111","volume":"121","author":[{"given":"Satyam","family":"Arora","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine Post Graduate Institute of Child Health (PGICH)  Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9653-9905","authenticated-orcid":false,"given":"Ruchika","family":"Goel","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and Pediatrics Simmons Cancer Institute at SIU School of Medicine  Springfield Illinois USA"},{"name":"Department of Pathology, Division of Transfusion Medicine, School of Medicine Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7415-4665","authenticated-orcid":false,"given":"Ratti Ram","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Post Graduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeeta","family":"Pahuja","sequence":"additional","affiliation":[{"name":"Department of Immunohaematology and Blood Transfusion Lady Hardinge Medical College and Associated Hospitals  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi","family":"Bhatnagar","sequence":"additional","affiliation":[{"name":"Department of Immunohaematology and Blood Transfusion B. J. Medical College  Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arif Vaheedu","family":"A A","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Government Medical College  Kollam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravneet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Government Medical College and Hospital  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somnath","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine All India Institute of Medical Science (AIIMS)  Bhubaneshwar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1982-5227","authenticated-orcid":false,"given":"Prasun","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Department of Immunohaematology and Blood Transfusion Medical College and Hospital  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubna","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Immunohaematology and Blood Transfusion (IHBT) GSVM Medical College  Kanpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arti","family":"Khatri","sequence":"additional","affiliation":[{"name":"Department of Pathology Chacha Nehru Bal Chikitsalaya (CNBC)  Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitu","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Sarojini Naidu Medical College  Agra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8801-708X","authenticated-orcid":false,"given":"Abhishekh","family":"B","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Jawaharlal Institute of Postgraduate Medical Education &amp; Research (JIPMER)  Puducherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7740-413X","authenticated-orcid":false,"given":"Romesh","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine and Blood Bank All India Institute of Medical Science (AIIMS)  Bhopal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gita","family":"Negi","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine All India Institute of Medical Science (AIIMS)  Rishikesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9796-2326","authenticated-orcid":false,"given":"Shamee","family":"Shastry","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion Kasturba Medical College, Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7684-8567","authenticated-orcid":false,"given":"Yashaswi","family":"Dhiman","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion, Himalayan Institute of Medical Sciences Swami Rama Himalayan University  Dehradun Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram Mohan","family":"Jaiswal","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion Mahatma Gandhi Medical College and Hospital  Jaipur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Rani","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Moti Lal Nehru Medical College  Prayagraj India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gajendra Nath","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Santokba Durlabhji Memorial Hospital  Jaipur Rajasthan India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3989-1432","authenticated-orcid":false,"given":"Srinivasarao","family":"Chunchu","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine ESIC Medical College  Sanathnagar Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimisha","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine ESIC Medical College &amp; 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