{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T01:08:58Z","timestamp":1783904938597,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>In March 2024, the Colombian National Food and Drug Surveillance Institute declared a shortage of anti\u2010RhD immunoglobulin, a critical product for preventing haemolytic disease of the foetus and newborn (HDFN) in RhD\u2010negative women carrying RhD\u2010positive foetuses. The aim of this work was to analyse the impact of this shortage on obstetric institutions, transfusion services and prophylactic management of the RhD\u2010negative pregnant population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A descriptive, cross\u2010sectional study was conducted using an online survey distributed between December 2024 and February 2025. Data were analysed according to region and experience with shortages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010seven institutions (17.9%) providing obstetric and transfusion services completed the survey. Most respondents (88.9%) represented obstetric services, followed by transfusion medicine (7.4%) and clinical pharmacy (3.7%). In 92.6% of institutions, physicians prescribed anti\u2010RhD immunoglobulin. Shortages were reported by 22.2% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096) of institutions. Prophylaxis was administered during weeks 28\u201340 in 51.9% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914) and during weeks 14\u201327 in 22.2% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096), while one reported both periods. Anti\u2010D administration was reported postpartum in 44.4% of cases, following abortion in 29.6%, after foetal haemorrhage in 7.4%, after trauma in 3.7% and once at the physician's discretion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although some institutions reported shortages of anti\u2010RhD immunoglobulin (particularly in the Andine region), these did not lead to changes in clinical indications, and prophylactic use during late pregnancy and the postpartum period remains the predominant practice nationwide.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.70250","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T03:57:01Z","timestamp":1773374221000},"page":"1076-1081","source":"Crossref","is-referenced-by-count":0,"title":["Use and availability of anti\u2010\n                    <scp>RhD<\/scp>\n                    immunoglobulin in Colombia following the 2024 national shortage"],"prefix":"10.1111","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6109-0495","authenticated-orcid":false,"given":"Mariana","family":"Barake\u2010Ramos","sequence":"first","affiliation":[{"name":"Applied Biomedical Sciences Research Group UR\u2010BIOMED, School of Medicine and Health Sciences Universidad del Rosario  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7530-4556","authenticated-orcid":false,"given":"Diego\u2010Andr\u00e9s","family":"Castillo\u2010Guerrero","sequence":"additional","affiliation":[{"name":"Applied Biomedical Sciences Research Group UR\u2010BIOMED, School of Medicine and Health Sciences Universidad del Rosario  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4716-078X","authenticated-orcid":false,"given":"Isabella","family":"Beltr\u00e1n\u2010Cardona","sequence":"additional","affiliation":[{"name":"Applied Biomedical Sciences Research Group UR\u2010BIOMED, School of Medicine and Health Sciences Universidad del Rosario  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5138-4671","authenticated-orcid":false,"given":"Oscar\u2010Daniel","family":"Bautista\u2010Manrique","sequence":"additional","affiliation":[{"name":"Applied Biomedical Sciences Research Group UR\u2010BIOMED, School of Medicine and Health Sciences Universidad del Rosario  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8715-4410","authenticated-orcid":false,"given":"Catalina","family":"Parra\u2010Galvis","sequence":"additional","affiliation":[{"name":"Applied Biomedical Sciences Research Group UR\u2010BIOMED, School of Medicine and Health Sciences Universidad del Rosario  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9637-8937","authenticated-orcid":false,"given":"Michel\u2010Andr\u00e9s","family":"Garc\u00eda\u2010Ot\u00e1lora","sequence":"additional","affiliation":[{"name":"Applied Biomedical Sciences Research Group UR\u2010BIOMED, School of Medicine and Health Sciences Universidad del Rosario  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1939.72800270002007a"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1982.tb00037.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13745"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","DOI":"10.18597\/rcog.4142","article-title":"Consenso colombiano de diagn\u00f3stico, prevenci\u00f3n y manejo de la enfermedad Rh","volume":"75","author":"Benavides\u2010Serralde JA","year":"2024","journal-title":"Rev Colomb Obstet Ginecol"},{"key":"e_1_2_9_6_1","unstructured":"Agencia Nacional de Referencia Regional. 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