{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T01:08:57Z","timestamp":1783904937500,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Paediatric patients with haematological disorders frequently require multiple blood transfusions, increasing their risk of developing irregular antibodies. Because of the immunohaematological differences from adults, patterns of alloimmunization in children may vary. This study aimed to determine the prevalence and characteristics of irregular antibodies in paediatric patients with haematological disorders at the National Institute of Hematology and Blood Transfusion (NIHBT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A total of 2663 paediatric patients with haematological disorders were screened for irregular antibodies using column agglutination technology. Positive samples underwent antibody identification. Associations between alloimmunization and clinical or transfusion\u2010related factors were assessed using univariate analyses and multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of irregular antibodies was 8.04% (95% confidence interval [CI]: 7.0\u20139.1). Among positive cases, 66.82% had a single antibody, most commonly anti\u2010E (35.51%) and anti\u2010Mi\n                      <jats:sup>a<\/jats:sup>\n                      (14.02%). The most frequent antibody combination was anti\u2010c and anti\u2010E (13.08%). Factors significantly associated with antibody formation after adjustment included a higher number of transfused red cell units (57.65 vs. 44.53\u2009units,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.000), absence of phenotype\u2010matched transfusions (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017), non\u2010Kinh ethnicity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0003) and a diagnosis of thalassaemia (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0013).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A relatively high prevalence of irregular red cell alloantibodies was observed in paediatric patients, predominantly involving antibodies of the Rh blood group system and anti\u2010Mi\u1d43. These findings support the relevance of targeted antigen matching in settings where fully phenotype\u2010matched red blood cells are not consistently available.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.70252","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T02:09:21Z","timestamp":1774404561000},"page":"1058-1064","source":"Crossref","is-referenced-by-count":0,"title":["Irregular antibodies in paediatric haematological disorders: Prevalence and characteristics from a Vietnamese tertiary centre"],"prefix":"10.1111","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7992-6209","authenticated-orcid":false,"given":"Tung Quang","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Hematology and Blood Transfusion Hanoi Medical University  Hanoi Vietnam"},{"name":"Department of Hematology and Transfusion Medicine Hanoi Medical University Hospital  Hanoi Vietnam"},{"name":"National Institute of Hematology and Blood Transfusion  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nga Thanh Thi","family":"Hoang","sequence":"additional","affiliation":[{"name":"Department of Blood Group Serology National Institute of Hematology and Blood Transfusion  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Thi","family":"Hoang","sequence":"additional","affiliation":[{"name":"Department of Hematology and Blood Transfusion Hanoi Medical University  Hanoi Vietnam"},{"name":"Pediatric Department National Institute of Hematology and Blood Transfusion  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha Thu Thi","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Thalassemia Center National Institute of Hematology and Blood Transfusion  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanh Ha","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Hematology and Blood Transfusion Hanoi Medical University  Hanoi Vietnam"},{"name":"National Institute of Hematology and Blood Transfusion  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-06-227793"},{"key":"e_1_2_9_3_1","first-page":"4","article-title":"Red blood cell alloimmunisation in transfusion\u2010dependent thalassaemia: a systematic review","volume":"17","author":"Franchini M","year":"2019","journal-title":"Blood Transfus"},{"key":"e_1_2_9_4_1","volume-title":"Red blood cell alloimmunization after blood transfusion","author":"Schonewille H","year":"2008"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1309\/LMBF1AT2HEVYUS7D"},{"key":"e_1_2_9_6_1","article-title":"Transfusion support and red cell alloimmunisation in thalassemia patients","volume":"2","author":"Dibyajyoti S","year":"2017","journal-title":"Haematol Int J"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jha2.645"},{"key":"e_1_2_9_8_1","first-page":"286","article-title":"T\u00ecnh h\u00ecnh d\u1ecbch t\u1ec5 mang gen thalassemia\/huy\u1ebft s\u1eafc t\u1ed1 m\u1ed9t s\u1ed1 d\u00e2n t\u1ed9c t\u1ea1i B\u1eafc Trung B\u1ed9","volume":"23","author":"Nguy\u1ec5n TTT","year":"2019","journal-title":"Ho Chi Minh City J Med"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14609"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2024.103878"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.13136"},{"key":"e_1_2_9_12_1","volume-title":"Technical Manual","author":"Cohn CS","year":"2023"},{"key":"e_1_2_9_13_1","volume-title":"Modern blood banking and transfusion practices","author":"Harmening DM","year":"2019"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12362"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12196"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.10.3369"},{"key":"e_1_2_9_17_1","first-page":"243","article-title":"Detection of irregular antibodies after blood transfusion for children with thalassaemia in Hainan","volume":"29","author":"Xu CL","year":"2021","journal-title":"Chin J Pathophysiol"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12348"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03234.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13695"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24397"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-013-0282-z"}],"container-title":["Vox 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