{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T01:08:49Z","timestamp":1783904929185,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:00:00Z","timestamp":1775952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:00:00Z","timestamp":1775952000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2026,7]]},"abstract":"Abstract<\/jats:title>\n \n Background and Objectives<\/jats:title>\n To evaluate the efficacy of intravenous immunoglobulin (IVIG) after plasma exchange (PE) in neonates with ABO haemolytic disease of the newborn (ABO\u2010HDN) by assessing serum biomarkers, neurodevelopment and quality of life.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n A total of 162 neonates with ABO\u2010HDN were randomly assigned to four groups: Control (\n n<\/jats:italic>\n \u2009=\u200939), IVIG (\n n<\/jats:italic>\n \u2009=\u200942), PE (\n n<\/jats:italic>\n \u2009=\u200941) and IVIG + PE (\n n<\/jats:italic>\n \u2009=\u200940). Serum markers, Neonatal Behavioural Neurological Assessment (NBNA), Echelle Douleur Inconfort Nouveau\u2010Ne and Paediatric Quality of Life Inventory (PedsQL4.0) scores were evaluated.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The IVIG + PE group showed the most significant improvement in prealbumin (PA), total bile acid (TBA), total bilirubin (TBIL), procalcitonin (PCT), high\u2010sensitivity C reactive protein (hs\u2010CRP) and antibody titre levels (\n p<\/jats:italic>\n \u2009<\u20090.05). Neurodevelopment, comfort and quality of life were significantly enhanced, with reduced jaundice duration and hospitalization time. Adverse event rates were lower in all treatment groups than in the control group (\n p<\/jats:italic>\n \u2009<\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n IVIG following PE improves serum biomarkers, antibody titre levels, neurodevelopment and quality of life in ABO\u2010HDN, supporting its clinical application.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/vox.70265","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T02:11:02Z","timestamp":1776046262000},"page":"1032-1040","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of intravenous immunoglobulin following plasma exchange in the management of\n ABO<\/scp>\n haemolytic disease of the newborn"],"prefix":"10.1111","volume":"121","author":[{"given":"Yahong","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Science The First Affiliated Hospital of Xi'an Jiaotong University East Campus Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7687-5561","authenticated-orcid":false,"given":"Jing","family":"Nie","sequence":"additional","affiliation":[{"name":"989 Hospital of the Joint Logistic Support Force of the Chinese People's Liberation Army Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-022-05329-z"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1709-5036"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2023.2228965"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18170"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12982"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.698541"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000470827"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-021-05289-0"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2023.103716"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-022-08210-z"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.864609"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-021-00963-5"},{"key":"e_1_2_9_14_1","first-page":"3173","article-title":"Study on the correlation of changes of IGF\u20101, GH, and NGB levels and NBNA score in neonates with hypoxic ischemic encephalopathy","volume":"22","author":"Liu G","year":"2018","journal-title":"Eur Rev Med Pharmacol 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