{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:12:09Z","timestamp":1788779529763,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Finding compatible blood donors for patients from minority racial and ethnic populations can be challenging due to differences in blood group antigen frequencies with the existing donor pool. Individuals with sickle cell trait (SCTrait) are allowed to donate in some countries, but in the Netherlands, carriers are currently not permitted to donate. This study estimates the incidence of adverse events among SCTrait donors compared with non\u2010SCTrait donors, to inform potential policy decisions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A retrospective study was performed at Sanquin, including whole\u2010blood (WB) and plasma donors, from 2012 to 2024. Adverse events related to donation were compared between SCTrait donors (identified retrospectively) and a control group of non\u2010SCTrait donors. Donor complications included systemic events, such as vasovagal reactions (VVRs), and venipuncture\u2010related complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 259 donations from 47 SCTrait donors and 2590 donations from 1371 non\u2010SCTrait donors were analysed. The overall rate of donor complications was low in both groups, with no differences observed between SCTrait and non\u2010SCTrait donors. VVR rates were 2.4% versus 2.7% in WB donations and 2.2% versus 1.0% in plasma donations for SCTrait versus non\u2010SCTrait donors, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Separation issues, like filter squirting in the plasma collection set, occurred in 10.0% of plasma donations from SCTrait donors versus 0.5% in non\u2010SCTrait donors (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The low incidence of adverse events among SCTrait donors suggests that blood donation is safe in this group. However, filter\u2010related issues do occur more frequently, and thus remain a point of concern.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.70271","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T01:10:52Z","timestamp":1776388252000},"page":"959-963","source":"Crossref","is-referenced-by-count":2,"title":["Evaluating blood donation safety for donors with sickle cell trait"],"prefix":"10.1111","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1791-6421","authenticated-orcid":false,"given":"Niubel D\u00edaz","family":"Padilla","sequence":"first","affiliation":[{"name":"Department of Donor Medicine Sanquin Blood Supply Foundation  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelis","family":"van der Torren","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Sanquin Blood Supply Foundation  Amsterdam the Netherlands"},{"name":"Department of Pediatric Hematology, Emma Children's Hospital, Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1648-9851","authenticated-orcid":false,"given":"Yared","family":"Paalvast","sequence":"additional","affiliation":[{"name":"Department of Donor Medicine Sanquin Blood Supply Foundation  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Kubbenga","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Sanquin Blood Supply Foundation  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3451-9911","authenticated-orcid":false,"given":"Johanna","family":"Wiersum\u2010Osselton","sequence":"additional","affiliation":[{"name":"Department of Donor Medicine Sanquin Blood Supply Foundation  Amsterdam the Netherlands"},{"name":"TRIP (Transfusion and Transplantation Reactions in Patients) Hemovigilance and Biovigilance Office  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"24","article-title":"Blood donation among individuals of African origin in the Netherlands: how are barriers and motivators associated with intention?","volume":"19","author":"Klinkenberg EF","year":"2021","journal-title":"Blood Transfus"},{"key":"e_1_2_9_3_1","first-page":"13","article-title":"Motivators and barriers to blood donation among potential donors of African and Caucasian ethnicity","volume":"21","author":"Fogarty H","year":"2023","journal-title":"Blood Transfus"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199006073222301"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24397"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019001143"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16405"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12445-023-2418-1"},{"key":"e_1_2_9_9_1","volume-title":"Guide to the preparation, use and quality assurance of bloodcomponents","author":"Council of Europe","year":"2025"},{"key":"e_1_2_9_10_1","volume-title":"Blood donor selection: guidelines on assessing donor suitability for blood donation","author":"World Health Organization","year":"2012"},{"key":"e_1_2_9_11_1","unstructured":"JPAC (Joint United Kingdom Blood Transfusion and Tissue Transplantation Services Professional Advisory Committee).Sickle\u2010cell trait. Whole blood and components donor selection guidelines Edition 203 Release 16. Available from:https:\/\/www.transfusionguidelines.org\/dsg\/wb\/guidelines\/si003-sickle-cell-trait. Last accessed 31 Jan 2026."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00206.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2004.03.002"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2021.103146"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17021"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17763"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13363"},{"key":"e_1_2_9_18_1","first-page":"s28","article-title":"Risk factors for complications in donors at first and repeat whole blood donation: a cohort study with assessment of the impact on donor return","volume":"12","author":"Wiersum\u2010Osselton JC","year":"2014","journal-title":"Blood Transfus"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17759"},{"key":"e_1_2_9_20_1","first-page":"281","article-title":"Vasovagal reactions in whole blood and apheresis donors: a cross\u2010sectional study on donor haemovigilance data from 2016 to 2019 in Italy","volume":"20","author":"Piccinini V","year":"2022","journal-title":"Blood Transfus"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3892\/mi.2025.221"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.15761\/HMO.1000179"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.14083"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.70271","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.70271","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.70271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:29:24Z","timestamp":1783902564000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.70271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,16]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/vox.70271"],"URL":"https:\/\/doi.org\/10.1111\/vox.70271","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,16]]}}}