{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T01:08:57Z","timestamp":1783904937498,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Vasovagal reaction (VVR) is the most frequent adverse reaction in blood donation, which usually recovers soon without complications. However, syncopal VVR can result in severe injury due to a fall. Some reports have shown the possibility to prevent VVR with salt\u2010loading prior to blood donation. This semi\u2010randomized controlled study aims to clarify the preventive effect of salt\u2010loading on VVR among whole blood (WB) donors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>During the study period, donors who donated 400 mL of WB on odd days were assigned to the salt\u2010loading group and those who donated on even days to the control group. Participants in the salt\u2010loading group were asked to take three tablets containing 0.3\u2009g salt in total.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The incidence of VVRs occurring &gt;20\u2009min after needle removal (delayed VVR [dVVR]) did not significantly differ between the two groups. Secondary analysis suggested a possible dose\u2010dependent preventive effect against dVVR (odds ratio [OR]: 0.70; 95% confidence interval [CI]: 0.52\u20130.94;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). The number of delayed syncopal VVR episodes in summer\u00a0was lower in the salt\u2010loading group than in the control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091 vs. 8; OR: 0.13;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04; pre\u2010specified\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2009=\u20090.0125).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There was no significant preventive effect of pre\u2010donation salt\u2010loading on VVR. Further investigations with sufficient number of participants are needed to conclude the suggested dose dependency and seasonal preventive effect on dVVRs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.70273","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T02:06:37Z","timestamp":1776909997000},"page":"964-970","source":"Crossref","is-referenced-by-count":0,"title":["Effects of pre\u2010donation salt\u2010loading on the occurrence of delayed vasovagal reactions"],"prefix":"10.1111","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2951-3451","authenticated-orcid":false,"given":"Noriko","family":"Namba","sequence":"first","affiliation":[{"name":"Japanese Red Cross Tokyo Metropolitan Blood Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaku","family":"Kondo","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Tokyo Metropolitan Blood Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7668-6083","authenticated-orcid":false,"given":"Fumihiko","family":"Ishimaru","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Blood Service Headquarters  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuma","family":"Hashizume","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Tokyo Metropolitan Blood Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshie","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Tokyo Metropolitan Blood Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Yano","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Tokyo Metropolitan Blood Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Tokyo Metropolitan Blood Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Kagawa","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Blood Service Headquarters  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miwa","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Tokyo Metropolitan Blood Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Kunii","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Tokyo Metropolitan Blood Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiharu","family":"Kano","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Tokyo Metropolitan Blood Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiichi","family":"Aoki","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Tokyo Metropolitan Blood Center  Tokyo Japan"},{"name":"Japanese Red Cross Blood Service Headquarters  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4393-7325","authenticated-orcid":false,"given":"Yoshihiro","family":"Sawamura","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Tokyo Metropolitan Blood Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeyoshi","family":"Makino","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Tokyo Metropolitan Blood Center  Tokyo Japan"},{"name":"Japanese Red Cross Blood Service Headquarters  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02397.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12418"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.18078"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12981"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03202.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13716"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16375"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17173"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13038"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13724"},{"key":"e_1_2_9_12_1","unstructured":"Japan Meteorological Agency.Tokyo (Tokyo Metropolis): Monthly Average of Daily Maximum Temperature (\u00b0C). Available from:https:\/\/www.data.jma.go.jp\/stats\/etrn\/view\/monthly_s3.php?prec_no=44&block_no=47662&year=&month=&day=&view=a2. Last accessed 30 Dec 2025."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(25)00319-9"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12120"},{"key":"e_1_2_9_15_1","unstructured":"Japan Meteorological Agency.Tokyo Metropolis 2025 (Monthly Values): Mean Temperature (\u00b0C). Available from:https:\/\/www.data.jma.go.jp\/stats\/etrn\/view\/monthly_h1.php?prec_no=44&block_no=00&year=2025&month=08&day=&view=p2. Last accessed 30 Dec 2025."},{"key":"e_1_2_9_16_1","unstructured":"Japan Meteorological Agency. Tokyo (Tokyo Metropolis): Monthly Average Relative Humidity (%). Available from:https:\/\/www.data.jma.go.jp\/stats\/etrn\/view\/monthly_s3.php?prec_no=44&block_no=47662&year=&month=&day=&view=a7. Last accessed 30 Dec 2025."},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.70072"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.70273","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.70273","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.70273","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:29:19Z","timestamp":1783902559000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.70273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,22]]},"references-count":16,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/vox.70273"],"URL":"https:\/\/doi.org\/10.1111\/vox.70273","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,22]]}}}