{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T02:28:54Z","timestamp":1786328934769,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2026,8]]},"abstract":"Abstract<\/jats:title>\n \n Background and Objectives<\/jats:title>\n \n The para\u2010Bombay phenotype is characterized by H antigen deficiency and the natural production of antibody against the I and H antigens (anti\u2010IH), some of which are occasionally clinically significant. It genetically results from the presence of two non\u2010functional\n FUT1<\/jats:italic>\n alleles coupled with at least one functional\n FUT2<\/jats:italic>\n allele. We present the serological and molecular characterization of a para\u2010Bombay phenotype case, which led to the identification of a novel\n FUT1<\/jats:italic>\n allele.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n A sample from a blood donor was identified as a result of a discrepancy between forward and reverse typing. This sample subsequently underwent serological typing for A, B and H antigens in accordance with the American Association of Blood Banks Technical Manual. Furthermore, Sanger sequencing and nanopore sequencing were employed to analyse the\n ABO<\/jats:italic>\n ,\n FUT1<\/jats:italic>\n and\n FUT2<\/jats:italic>\n genes.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The donor was found to have an H\u2010deficient phenotype and the presence of anti\u2010IH. Sanger sequencing identified an\n ABO<\/jats:italic>\n *\n A1.01\/ABO<\/jats:italic>\n *\n O.01.02<\/jats:italic>\n genotype. Nanopore sequencing showed a compound heterozygous state in FUT1, represented by the\n FUT1<\/jats:italic>\n *\n 01W.09<\/jats:italic>\n allele and a novel\n FUT1<\/jats:italic>\n allele carrying the c.[35C>T;133_136dupCGCC] variant. The\n FUT2<\/jats:italic>\n genotype was determined as\n FUT2<\/jats:italic>\n *\n 01\/FUT2<\/jats:italic>\n *\n 01W.02.01<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This study identifies a novel\n FUT1<\/jats:italic>\n allele characterized by the c.[35C>T;133_136dupCGCC] variant that impairs H antigen expression on red blood cells, thereby contributing to the understanding of\n FUT1<\/jats:italic>\n allele diversity.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/vox.70288","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T01:50:40Z","timestamp":1779673840000},"page":"1250-1255","source":"Crossref","is-referenced-by-count":0,"title":["A novel\n \n FUT1<\/i>\n <\/scp>\n variant,\n c.[35C>T;133_136dupCGCC]<\/scp>\n , underlies a group A para\u2010Bombay phenotype in a Chinese blood donor"],"prefix":"10.1111","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3394-4625","authenticated-orcid":false,"given":"Jue","family":"Hou","sequence":"first","affiliation":[{"name":"Blood Grouping Reference Laboratory Chengdu Blood Center Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Chen","sequence":"additional","affiliation":[{"name":"Blood Grouping Reference Laboratory Chengdu Blood Center Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Blood Grouping Reference Laboratory Chengdu Blood Center Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianying","family":"Yang","sequence":"additional","affiliation":[{"name":"Blood Grouping Reference Laboratory Chengdu Blood Center Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Blood Grouping Reference Laboratory Chengdu Blood Center Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.21307\/immunohematology-2019-056"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsb832"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.13.5843"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.9.4632"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-1809.2001.6550429.x"},{"key":"e_1_2_9_7_1","unstructured":"International Society of Blood Transfusion.Names for H (ISBT 018) blood group alleles. 2023. Available from:https:\/\/blooddatabase.isbtweb.org\/system\/H. Last accessed 14 May 2026."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-44731-1"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.01045.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03209.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2000.40070828.x"},{"key":"e_1_2_9_12_1","volume-title":"AABB technical manual","author":"Fung MK","year":"2017"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2009.01291.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17339"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.18362"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.70295"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12183"},{"key":"e_1_2_9_18_1","first-page":"472","article-title":"Genomic analysis of para\u2010Bombay individuals in south\u2010eastern China: the possibility of linkage and disequilibrium between FUT1 and FUT2","volume":"13","author":"Zhang A","year":"2015","journal-title":"Blood Transfus"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02293.x"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.70288","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.70288","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.70288","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T01:50:56Z","timestamp":1786326656000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.70288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,24]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/vox.70288"],"URL":"https:\/\/doi.org\/10.1111\/vox.70288","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,24]]}}}