{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:18:58Z","timestamp":1789165138008,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100015539","name":"Australian Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015539","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2026,9]]},"abstract":"Abstract<\/jats:title>\n \n Background and Objectives<\/jats:title>\n Plasma and cryoprecipitate are stored below \u221225\u00b0C for optimal preservation of component quality. However, there may be situations in which components are exposed to higher temperatures and therefore discarded. This study aimed to determine the quality of plasma and cryoprecipitate following a short\u2010term temperature excursion to inform a possible shelf life.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n Apheresis and whole blood (WB)\u2010derived fresh frozen plasma (FFP;\n n<\/jats:italic>\n \u2009=\u200968 and\n n<\/jats:italic>\n \u2009=\u200937, respectively) and cryoprecipitate components (apheresis\n n<\/jats:italic>\n \u2009=\u200978 and WB\n n<\/jats:italic>\n \u2009=\u200980) that incurred a temperature excursion up to \u221211\u00b0C were returned to \u221225\u00b0C. Coagulation factors were measured at 1 month (baseline), 3 months and 6 months post excursion.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n There were no significant differences in factor VIII (FVIII) concentrations in apheresis\u2010 and WB\u2010derived plasma and apheresis\u2010derived cryoprecipitate between 1\u2009month, 3\u2009months and 6\u2009months (\n p<\/jats:italic>\n \u2009=\u20090.236,\n p<\/jats:italic>\n \u2009=\u20090.249 and\n p<\/jats:italic>\n \u2009=\u20090.815, respectively). Activated partial thromboplastin time and prothrombin time increased slightly in plasma over storage but were not significantly different from baseline. Fibrinogen, von Willebrand Factor (VWF), protein C and immunoglobulin G were stable in plasma and cryoprecipitate.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The data demonstrate that plasma and cryoprecipitate that incurred a temperature excursion can meet quality control specifications when stored for 6\u2009months post temperature excursion.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/vox.70302","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T02:38:51Z","timestamp":1780022331000},"page":"1420-1424","source":"Crossref","is-referenced-by-count":0,"title":["Short\u2010term temperature excursion does not affect plasma and cryoprecipitate quality"],"prefix":"10.1111","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8423-3618","authenticated-orcid":false,"given":"Kelly M.","family":"Winter","sequence":"first","affiliation":[{"name":"Research and Development Australian Red Cross Lifeblood Alexandria New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel G.","family":"Webb","sequence":"additional","affiliation":[{"name":"Research and Development Australian Red Cross Lifeblood Alexandria New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Mazur","sequence":"additional","affiliation":[{"name":"Research and Development Australian Red Cross Lifeblood Alexandria New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peta M.","family":"Dennington","sequence":"additional","affiliation":[{"name":"Pathology Services Australian Red Cross Lifeblood Alexandria New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3674-6934","authenticated-orcid":false,"given":"Denese C.","family":"Marks","sequence":"additional","affiliation":[{"name":"Research and Development Australian Red Cross Lifeblood Alexandria New South Wales Australia"},{"name":"Sydney Medical School The University of Sydney Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02648.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2009.03.001"},{"key":"e_1_2_9_4_1","volume-title":"Guide to the preparation, use and quality assurance of blood components","year":"2017"},{"key":"e_1_2_9_5_1","unstructured":"Association for the Advancement of Blood & Biotherapies.Blood component card. Available from:https:\/\/www.aabb.org\/docs\/default\u2010source\/default\u2010document\u2010library\/resources\/blood\u2010component\u2010cards.pdf?sfvrsn=7f337fd7_4. Last accessed 3 Dec 2025."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15963"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1778-428X.2010.01129.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12914"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2007.00729.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13189"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.03028.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12222"},{"key":"e_1_2_9_13_1","unstructured":"The Royal College of Pathologists of Australia.RCPA manual. Available from:https:\/\/www.rcpa.edu.au\/Manuals\/RCPA-Manual. Last accessed 27 Aug 2025."}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.70302","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.70302","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.70302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:58:45Z","timestamp":1789163925000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.70302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,28]]},"references-count":12,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/vox.70302"],"URL":"https:\/\/doi.org\/10.1111\/vox.70302","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,28]]}}}