{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:18:55Z","timestamp":1789165135530,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Selective immunoglobulin A (IgA) deficiency is the most common human immunodeficiency, affecting approximately 1 in 500\u2013800 individuals of European ancestry. It is defined by a serum IgA level below 7\u2009mg\/dL, with normal immunoglobulin G (IgG) and immunoglobulin M (IgM) levels. Since 1968, severe allergic transfusion reactions have been reported in IgA\u2010deficient patients, often linked to anti\u2010IgA antibodies. This led to recommendations for using IgA\u2010deficient blood components in affected individuals. However, due to the rarity of such reactions, standardized and evidence\u2010based guidelines are lacking, while blood services face logistical challenges maintaining registries of IgA\u2010deficient donors and inventories of compatible products.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>An international survey was conducted to assess current practices in managing IgA deficiency. The survey explored the frequency of transfusion reactions involving IgA\/anti\u2010IgA, detection methods for IgA deficiency and anti\u2010IgA antibodies, reasons for requesting IgA\u2010deficient products, product availability and strategies to facilitate access to IgA\u2010deficient products.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Participants from 14 countries\/regions across four continents reported a wide variability in defining IgA deficiency, criteria for recommending IgA\u2010deficient products and anti\u2010IgA testing practices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings highlight the need for international reference standards and harmonized recommendations to improve the management of IgA\u2010deficient patients. Establishing harmonized best practices and evidence\u2010based guidelines should enhance patient safety and support clinical decision making globally.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.70311","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T07:46:02Z","timestamp":1781163962000},"page":"1385-1392","source":"Crossref","is-referenced-by-count":0,"title":["International survey on the management of IgA deficiency: The\n                    <scp>BEST<\/scp>\n                    Collaborative Study"],"prefix":"10.1111","volume":"121","author":[{"given":"Ren\u00e9e","family":"Bazin","sequence":"first","affiliation":[{"name":"Medical Affairs and Innovation H\u00e9ma\u2010Qu\u00e9bec  Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9904-9952","authenticated-orcid":false,"given":"Mindy","family":"Goldman","sequence":"additional","affiliation":[{"name":"Donation Policy and Studies Canadian Blood Services  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin G.","family":"Eichbaum","sequence":"additional","affiliation":[{"name":"Roswell Park Comprehensive Cancer Center  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8823-2719","authenticated-orcid":false,"given":"Torunn Oveland","family":"Apelseth","sequence":"additional","affiliation":[{"name":"Norwegian Center for Blood Preparedness, Department of Immunology and Transfusion Medicine Haukeland University Hospital  Bergen Norway"},{"name":"Faculty of Medicine University of Bergen  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7675-3197","authenticated-orcid":false,"given":"Catherine","family":"Latour","sequence":"additional","affiliation":[{"name":"Transfusion Medicine H\u00e9ma\u2010Qu\u00e9bec  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1748-4198","authenticated-orcid":false,"given":"Antoine","family":"Lewin","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation H\u00e9ma\u2010Qu\u00e9bec  Montreal Quebec Canada"},{"name":"Department of Mathematics, Faculty of Science Sherbrooke University  Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0450-1818","authenticated-orcid":false,"given":"Nancy","family":"Robitaille","sequence":"additional","affiliation":[{"name":"Transfusion Medicine H\u00e9ma\u2010Qu\u00e9bec  Montreal Quebec Canada"},{"name":"Division of Hematology and Oncology, Department of Pediatrics CHU Sainte\u2010Justine  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Biomedical Excellence for Safer Transfusion Collaborative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"205","article-title":"Beta\u20102a aglobulinemia in two healthy men","volume":"63","author":"Rockey JH","year":"1964","journal-title":"J Lab Clin Med"},{"key":"e_1_2_9_3_1","first-page":"838","article-title":"Healthy blood donors with selective absence of immunoglobulin A: prevention of anaphylactic transfusion reactions caused by antibodies to IgA","volume":"85","author":"Vyas GN","year":"1975","journal-title":"J Lab Clin Med"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1975.tb00494.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.30.11.1007"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.01037.x"},{"key":"e_1_2_9_7_1","unstructured":"ESID Registry Working Party.ESID registry \u2013 working definitions for clinical diagnosis of PID. 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