{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:18:58Z","timestamp":1789165138535,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006432","name":"Terumo BCT","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006432","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Di(2\u2010ethylhexyl) phthalate (DEHP) has been classified as a reproductive toxicant and endocrine disruptor and will be banned in the European Union (EU) in blood bags starting in July 2030. Alternative plasticizers are being developed, and this study is the first to report on platelets and plasma collected using investigational non\u2010DEHP apheresis sets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Randomized, crossover collections of platelet and plasma products from identical participants in DEHP and non\u2010DEHP sets were performed. Plasma was studied as fresh frozen plasma (FFP) and stored in non\u2010DEHP bags. Additional plasma\u2010only collections evaluated plasma frozen within 24\u2009h after phlebotomy and held at room temperature for up to 24\u2009h (PF24RT24). Platelet and plasma quality parameters were evaluated against the US Food and Drug Administration (FDA) and the European Directorate for the Quality of Medicines &amp; HealthCare (EDQM) criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Platelet products (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200933 pairs) met all FDA\/EDQM standards, and in vitro parameters were within the predetermined 20% equivalency margin. FFP products (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200933 pairs) met the EDQM criteria. Factor VIII retention after \u226530\u2009days of frozen storage was on average 88.4%. All parameters for PF24RT24 products (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931 pairs) met the 20% equivalency margin after &gt;31\u2009days of frozen storage. No serious adverse events in study participants were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Non\u2010DEHP apheresis disposable sets collect transfusion\u2010quality platelet and plasma components, supporting the phasing out of DEHP and reducing exposure to this plasticizer, without compromising participant safety and quality of the collected products.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.70318","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T01:55:55Z","timestamp":1782266155000},"page":"1338-1346","source":"Crossref","is-referenced-by-count":0,"title":["In vitro evaluation of apheresis platelet and plasma products collected and stored in non\u2010\n                    <scp>DEHP<\/scp>\n                    disposable sets"],"prefix":"10.1111","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7862-6201","authenticated-orcid":false,"given":"Susanne","family":"Marschner","sequence":"first","affiliation":[{"name":"Vitalant Research Institute  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9352-2585","authenticated-orcid":false,"given":"Caroline R.","family":"Alquist","sequence":"additional","affiliation":[{"name":"Hoxworth Blood Center University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8595-8856","authenticated-orcid":false,"given":"Bethany","family":"Brown","sequence":"additional","affiliation":[{"name":"American Red Cross  Rockville Maryland USA"},{"name":"American Red Cross  Norfolk Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D.","family":"Rice","sequence":"additional","affiliation":[{"name":"Terumo Blood and Cell Technologies  Lakewood Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Gloor","sequence":"additional","affiliation":[{"name":"Terumo Blood and Cell Technologies  Lakewood Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremiah","family":"Gorman","sequence":"additional","affiliation":[{"name":"Terumo Blood and Cell Technologies  Lakewood Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Sedjo","sequence":"additional","affiliation":[{"name":"Terumo Blood and Cell Technologies  Lakewood Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Mason","sequence":"additional","affiliation":[{"name":"Terumo Blood and Cell Technologies  Lakewood Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack P.","family":"Rhodes","sequence":"additional","affiliation":[{"name":"Terumo Blood and Cell Technologies  Lakewood Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Terumo Blood and Cell Technologies  Lakewood Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeta","family":"Rugg","sequence":"additional","affiliation":[{"name":"Hoxworth Blood Center University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Cook","sequence":"additional","affiliation":[{"name":"Lifetime Scientific, Inc.  Dundas Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha E.","family":"Mack","sequence":"additional","affiliation":[{"name":"Vitalant Research Institute  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.7303103"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12982"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197211302872203"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.170.3956.460"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018029629"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/58.2.339"},{"key":"e_1_2_9_8_1","unstructured":"The European Commission.Commission regulation (EU) 2023\/2482 of 13 November 2023 amending regulation (EC) No 1907\/2006 (REACH) as regards DEHP in medical devices. Official Journal of the European Union. Available from:https:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/HTML\/?uri=OJ:L_202302482. Last accessed 9 Mar 2026."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.13091"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12870"},{"key":"e_1_2_9_11_1","unstructured":"The European Pharmacopeia.The Ph. Eur. revised its general chapters on plasticised PVC materials. Available from:https:\/\/www.edqm.eu\/en\/\u2010\/the\u2010ph.\u2010eur.\u2010revised\u2010its\u2010general\u2010chapters\u2010on\u2010plasticised\u2010pvc\u2010materials;https:\/\/www.edqm.eu\/en\/european-pharmacopoeia-new-online-only-12th-edition. Last accessed 9 Mar 2026."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1975.15576082215.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00829.x"},{"key":"e_1_2_9_14_1","volume-title":"Standards for blood banks and transfusion services","author":"Galel S","year":"2024"},{"key":"e_1_2_9_15_1","volume-title":"Guide to the preparation, use and quality assurance of blood components","author":"Council of Europe","year":"2024"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2011.03.005"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12528"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12084"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.70151"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.5.e429"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2025.150904"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.70087"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.70318","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.70318","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.70318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:58:47Z","timestamp":1789163927000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.70318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,23]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/vox.70318"],"URL":"https:\/\/doi.org\/10.1111\/vox.70318","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,23]]}}}