{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:18:52Z","timestamp":1789165132980,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Iron deficiency without anaemia (IDWA) is a significant concern among blood donors. Reticulocyte haemoglobin content (RHC) has been increasingly investigated as an alternative biomarker to evaluate iron status, but its diagnostic performance remains unclear. We aim to assess the diagnostic accuracy of RHC for detecting iron deficiency in non\u2010anaemic blood donors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      PubMed, Embase, Scopus, Web of Science, Cochrane Library, ProQuest Dissertations &amp; Theses, trial registries and reference lists were searched. Study quality was assessed using the Revised Tool for\u00a0Quality Assessment of Diagnostic Accuracy Studies (QUADAS\u20102), and the certainty of evidence was assessed using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. The pooled sensitivity, specificity, likelihood ratios (LRs) and summary receiver operating characteristic area under the curve (SROC\n                      <jats:sub>AUC<\/jats:sub>\n                      ) were estimated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirteen studies involving 5853 donors were included. The pooled sensitivity, specificity, positive LR (LR+) and negative LR (LR\u2212) of RHC to evaluate iron deficiency compared to tests using ferritin, soluble transferrin receptor or a combination of parameters were 0.70 (95% confidence interval [CI]: 0.60\u20130.79), 0.85 (95% CI: 0.74\u20130.92), 4.84 (95% CI: 2.59\u20139.04) and 0.35 (95% CI: 0.25\u20130.48), respectively; the SROC\n                      <jats:sub>AUC<\/jats:sub>\n                      was 0.82. The certainty of evidence was rated as very low to low.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Evidence from this review is insufficient to support the widespread use of RHC as a standalone screening test for IDWA in blood donors. Further studies are needed to improve RHC\u2010based screening strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.70321","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:45:20Z","timestamp":1783903520000},"page":"1301-1311","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic accuracy of reticulocyte haemoglobin content in detecting iron deficiency without anaemia in blood donors: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"121","author":[{"given":"Peerawit","family":"Yanyiam","sequence":"first","affiliation":[{"name":"Department of Pathology Faculty of Medicine, Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanoot","family":"Jaruthamsophon","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine, Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0718-1601","authenticated-orcid":false,"given":"Kantarat","family":"Kusolthammarat","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine, Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03062.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2009.00979.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02865.x"},{"key":"e_1_2_9_5_1","unstructured":"AABB Ad Hoc Iron Deficiency Working Group.AABB donor iron deficiency risk\u2010based decision\u2010making assessment report.2018. Available from:https:\/\/www.aabb.org\/docs\/default\u2010source\/default\u2010document\u2010library\/resources\/aabb\u2010donor\u2010iron\u2010deficiency\u2010rbdm\u2010assessment\u2010report.pdf?sfvrsn=f89b09de_0. Last accessed 8 Dec 2025."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12518"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13956"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S375945"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2024.150860"},{"key":"e_1_2_9_10_1","unstructured":"SzczepiorkowskiZ HopkinsT.Updated strategies to limit or prevent iron deficiency in blood donors Association Bulletin #17\u201002.2022. Available from:https:\/\/www.aabb.org\/docs\/default-source\/default-document-library\/resources\/association-bulletins\/ab17-02.pdf. Last accessed 5 Jun 2026."},{"key":"e_1_2_9_11_1","volume-title":"WHO guideline on use of ferritin concentrations to assess iron status in individuals and populations","author":"World Health Organization (WHO)","year":"2020"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13216"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.2006.00812.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21090"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.13957"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12500"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.19163"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m2632"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2015.16.6.1188"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-6-31"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2005.01.016"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jalm\/jfaf078"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.70023"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2025.104258"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.35787\/jimdc.v13i2.1145"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-023-01683-w"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13525"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2023.103781"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12700"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2015.03.011"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12209"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2011.12.006"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2008.00862.x"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPCVZ5B0BOYJGN"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9050450"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-017-2212-6"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12705"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.3.818.bloodjournal853818"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.10.3100.3100"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/lmz099"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjhh.2014.09.004"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13775"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.70321","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.70321","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.70321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:58:09Z","timestamp":1789163889000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.70321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,12]]},"references-count":41,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/vox.70321"],"URL":"https:\/\/doi.org\/10.1111\/vox.70321","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,12]]}}}