{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T08:08:47Z","timestamp":1784534927729,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009480","name":"Stichting Vrienden van het Sophia","doi-asserted-by":"publisher","award":["OTH22\u201007"],"award-info":[{"award-number":["OTH22\u201007"]}],"id":[{"id":"10.13039\/501100009480","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"abstract":"Abstract<\/jats:title>\n \n Background and Objectives<\/jats:title>\n Umbilical cord blood (UCB) as a source for red blood cell (RBC) transfusions is a promising alternative to adult RBC transfusions in extremely preterm neonates, as UCB contains predominantly fetal haemoglobin (HbF). A limitation to clinical use is the low and variable yield of UCB collections. This study aimed to assess UCB collection volume and feasibility across three techniques in uncomplicated term pregnancies.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n We conducted a prospective observational study in two centres in The Netherlands. We compared the volume of UCB units collected from uncomplicated term deliveries using three different techniques: in utero, ex utero with a funnel and ex utero with a plateau. A minimum target volume of 70\u2009mL was deemed adequate for further processing.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 606 collection attempts, 570 (94%) were successful. The median UCB volume was 65\u2009mL (interquartile range, IQR 49\u201384), with 242 (42.5%) collections \u226570\u2009mL. Volumes differed significantly between the three techniques, with the ex utero plateau technique yielding the highest median volume (70\u2009mL, IQR 55\u201388), followed by in utero (56\u2009mL, IQR 45\u201371) and the funnel technique (36\u2009mL, IQR 30\u201351) (\n p<\/jats:italic>\n \u2009<\u20090.001). UCB volume correlated with birth weight (\n p<\/jats:italic>\n \u2009<\u20090.001), but not with gestational age or sex. Volumes obtained with the plateau technique increased over time, suggesting a learning\u2010curve effect.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Collected UCB volume was highest using the ex utero plateau technique and was associated with birth weight and operator experience. The observed learning curve underscores the importance of dedicated teams to maximize UCB collection efficiency for future transfusion use.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/vox.70331","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T07:55:22Z","timestamp":1784534122000},"source":"Crossref","is-referenced-by-count":0,"title":["Comparing the volume of umbilical cord blood collection using different techniques"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3245-9797","authenticated-orcid":false,"given":"Jip H.","family":"van Daelen","sequence":"first","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics Erasmus MC Sophia Children's Hospital, Erasmus Medical University Center Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Cortesi","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianne I.","family":"Verbeek","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5725-0594","authenticated-orcid":false,"given":"Sophie J. E.","family":"Cramer","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0700-2194","authenticated-orcid":false,"given":"Elise J.","family":"Huisman","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology, Department of Pediatrics Erasmus MC Sophia Children's Hospital, Erasmus Medical University Center Rotterdam the Netherlands"},{"name":"Department of Medical Affairs, Unit of Transfusion Medicine Sanquin Blood Bank Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R. L.","family":"Klei","sequence":"additional","affiliation":[{"name":"Department of Product and Process Development Sanquin Blood Supply Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irwin K. M.","family":"Reiss","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics Erasmus MC Sophia Children's Hospital, Erasmus Medical University Center Rotterdam the Netherlands"},{"name":"Division of Neonatology and Pediatric Intensive Care University Children's Hospital, University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline M.","family":"Snijder","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics Erasmus MC Sophia Children's Hospital, Erasmus Medical University Center Rotterdam the Netherlands"},{"name":"Department of Medical Affairs, Unit of Transfusion Medicine Sanquin Blood Bank Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3513-5066","authenticated-orcid":false,"given":"Enrico","family":"Lopriore","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s13052-024-01714-w","article-title":"Cord blood transfusions in extremely low gestational age neonates to reduce severe retinopathy of prematurity: results of a prespecified interim analysis of the randomized BORN trial","volume":"50","author":"Teofili L","year":"2024","journal-title":"Ital J Pediatr"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1001\/jama.2016.1204","article-title":"Association of red blood cell transfusion, anemia, and necrotizing enterocolitis in very low\u2010birth\u2010weight infants","volume":"315","author":"Patel RM","year":"2016","journal-title":"Jama"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1136\/bjophthalmol-2020-318293","article-title":"Low fraction of fetal haemoglobin is associated with retinopathy of prematurity in the very preterm infant","volume":"106","author":"Hellstr\u00f6m W","year":"2022","journal-title":"Br J Ophthalmol"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1136\/archdischild-2020-319181","article-title":"Fetal haemoglobin and bronchopulmonary dysplasia in neonates: an observational study","volume":"106","author":"Hellstr\u00f6m W","year":"2021","journal-title":"Arch Dis Child Fetal Neonatal ed"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1016\/S2352-3026(15)00005-8","article-title":"Safety and efficacy of allogeneic umbilical cord red blood cell transfusion for children with severe anaemia in a Kenyan hospital: an open\u2010label single\u2010arm trial","volume":"2","author":"Hassall OW","year":"2015","journal-title":"Lancet Haematol"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/bjh.16851","article-title":"Allogeneic cord blood transfusions prevent fetal haemoglobin depletion in preterm neonates. 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