{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T02:24:58Z","timestamp":1787106298473,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Hepatitis E virus (HEV) is a recognized transfusion\u2010transmissible pathogen with significant impact in immunocompromised recipients. Data from Southeast Asia are limited, and the epidemiology of HEV in Muslim\u2010majority populations with low pork consumption remains poorly characterized. This study aimed to determine anti\u2010HEV immunoglobulin G (IgG) and immunoglobulin M (IgM)\u00a0seroprevalence and associated demographic, dietary, environmental, zoonotic and knowledge\u2010related factors among Malaysian blood donors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A prospective cross\u2010sectional study was conducted among 500 consecutive blood donors at the Universiti Malaya Medical Centre. Anti\u2010HEV IgG and IgM were measured using enzyme\u2010linked immunosorbent assay. A structured questionnaire assessed demographic, dietary, environmental and zoonotic exposures. Univariate and multivariable logistic regression identified predictors of anti\u2010HEV IgG seropositivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Anti\u2010HEV IgG seroprevalence was 2.8% (14\/500), and IgM positivity was 0.6% (3\/500). IgG seropositivity increased with age but showed no association with dietary exposures, including pork consumption. Knowledge of HEV was low, with a median score of 1 out of 12. Multivariable analysis identified freshwater recreational exposure (adjusted odds ratio [aOR] 20.04;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017) and direct rodent contact (aOR 13.36;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030) as factors associated with anti\u2010HEV IgG seropositivity; however, these findings were based on small numbers of exposed individuals and should be interpreted cautiously.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HEV seroprevalence in Malaysian blood donors was low, indicating a limited burden of previous HEV infection. The observed epidemiological profile suggests that environmental and zoonotic exposures may be associated with HEV seropositivity, although these findings require cautious interpretation. These findings provide baseline data for continued surveillance and future evaluation of transfusion\u2010transmitted HEV risk in Malaysia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.70336","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T01:30:42Z","timestamp":1787103042000},"source":"Crossref","is-referenced-by-count":0,"title":["Hepatitis\n                    <scp>E<\/scp>\n                    virus seroepidemiology among Malaysian blood donors: Prevalence and associated risk factors"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3073-5502","authenticated-orcid":false,"given":"Christina Lai Ling","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine Universiti Malaya Medical Centre  Kuala Lumpur Malaysia"},{"name":"Department of Medicine, Faculty of Medicine Universiti Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0107-0532","authenticated-orcid":false,"given":"Li Ping","family":"Wong","sequence":"additional","affiliation":[{"name":"Center for Population Health (CePH), Department of Social and Preventive Medicine, Faculty of Medicine Universiti Malaya  Kuala Lumpur Malaysia"},{"name":"Department of Epidemiology and Health Statistics, School of Public Health Fujian Medical University  Fuzhou Fujian People's Republic of China"},{"name":"Department of Medicine, College of Medicine Korea University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0783-6340","authenticated-orcid":false,"given":"Lee Lee","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine Universiti Malaya  Kuala Lumpur 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Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7650-3103","authenticated-orcid":false,"given":"Shi Ya","family":"Chang","sequence":"additional","affiliation":[{"name":"Universiti Sains Malaysia  Pulau Pinang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9470-4313","authenticated-orcid":false,"given":"Mohammad Izzad","family":"Ishak","sequence":"additional","affiliation":[{"name":"Universiti Sains Malaysia  Pulau Pinang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2765-0147","authenticated-orcid":false,"given":"Mun Sin","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, Faculty of Medicine Universiti Malaya  Kuala Lumpur 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