{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T08:46:56Z","timestamp":1785746816295,"version":"3.56.0"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF23OC0086419"],"award-info":[{"award-number":["NNF23OC0086419"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF23OC0082015"],"award-info":[{"award-number":["NNF23OC0082015"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF17OC0027864"],"award-info":[{"award-number":["NNF17OC0027864"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF17OC0027594"],"award-info":[{"award-number":["NNF17OC0027594"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004836","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","award":["09\u2013069412"],"award-info":[{"award-number":["09\u2013069412"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>In Denmark, increasing demand for plasma\u2010derived medicinal products has made plasma self\u2010sufficiency based on voluntary, non\u2010remunerated donation a political priority. This report describes recent developments in plasma collection, with a focus on the Central Denmark Region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Plasma capacity was expanded progressively over time through dedicated units, increased staffing and donor\u2010focused initiatives in the Central Denmark Region, particularly in 2024. National and regional donation trends were described for 2016\u20132025. Donor characteristics and donation frequency were summarized for the Central Denmark Region. Plasma self\u2010sufficiency was calculated assuming an immunoglobulin yield of 5\u2009g\/kg plasma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 2016 to 2025, national plasma donations increased by 167% reaching 161,438 donations in 2025, corresponding to 65% self\u2010sufficiency. In the same period, plasma donations in the Central Denmark Region increased more than threefold to 41,268 corresponding to 70% self\u2010sufficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Plasma collection can be substantially expanded within a voluntary, non\u2010remunerated system. In the Central Denmark Region, dedicated infrastructure and targeted recruitment and retention were associated with a more than threefold increase in donations and 70% self\u2010sufficiency, achieved through a single plasma centre in a region with 1.4 million inhabitants. The opening of four additional small facilities (November 2025\u2013April 2026) supports projected full self\u2010sufficiency within 1\u20132\u2009years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.70339","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T08:11:56Z","timestamp":1785744716000},"source":"Crossref","is-referenced-by-count":0,"title":["Voluntary non\u2010remunerated plasma collection in Denmark: Experiences from the Central Denmark Region"],"prefix":"10.1111","author":[{"given":"Kathrine Agerg\u00e5rd","family":"Kaspersen","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital  Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte","family":"Hindhede","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital  Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital  Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilie Munck","family":"Bjerre","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital  Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Louise","family":"P\u00f8rtner","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital  Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise \u00d8rnskov","family":"Drechsler","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital  Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2945-6197","authenticated-orcid":false,"given":"Christina","family":"Mikkelsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"},{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science Copenhagen University  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole Birger","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Zealand University Hospital  K\u00f8ge Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisse Rye","family":"Ostrowski","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betina Samuelsen","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bitten","family":"Aagaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mie Topholm","family":"Bruun","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjarne Kuno","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital  Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Erikstrup","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital  Aarhus N Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13758"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13491"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13540"},{"key":"e_1_2_9_5_1","unstructured":"Self\u2010sufficiency in blood and blood products. Available from:https:\/\/www.who.int\/teams\/health\u2010product\u2010policy\u2010and\u2010standards\/standards\u2010and\u2010specifications\/blood\u2010and\u2010products\u2010of\u2010human\u2010origin\/self\u2010sufficiency\u2010in\u2010blood\u2010and\u2010blood\u2010products. Last accessed 19 Mar 2026."},{"key":"e_1_2_9_6_1","unstructured":"Supply Project\u2014strengthening plasma collection capacity in Europe. Supply Project. Available from:https:\/\/supply-project.eu\/. Last accessed 19 Mar 2026."},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13613"},{"key":"e_1_2_9_8_1","unstructured":"Redattore.Plasma: new record in 2025 with nearly 920 tonnes collected. Centro Nazionale Sangue. 2026. Available from:https:\/\/www.centronazionalesangue.it\/en\/plasma\u2010new\u2010record\u2010in\u20102025\u2010with\u2010nearly\u2010920\u2010tonnes\u2010collected\/. Last accessed 12 May 2026."},{"key":"e_1_2_9_9_1","unstructured":"Service FN.Red Cross Flanders seeks 25 000 new plasma donors to boost self\u2010sufficiency. belganewsagency.eu. 2025. Available from:https:\/\/www.belganewsagency.eu\/red-cross-flanders-seeks-25000-new-plasma-donors-to-boost-self-sufficiency. Last accessed 12 May 2026."},{"key":"e_1_2_9_10_1","unstructured":"Danmarks Statistik. Available from:https:\/\/www.dst.dk\/da\/Statistik\/emner\/borgere\/befolkning\/befolkningstal. Last accessed 19 Mar 2026."},{"key":"e_1_2_9_11_1","unstructured":"CSL Behring Danmark. Available from:https:\/\/www.cslbehring.dk\/. Last accessed 19 Mar 2026."},{"key":"e_1_2_9_12_1","unstructured":"Amgros I\/S. Available from:https:\/\/amgros.dk\/home\/. Last accessed 19 Mar 2026."},{"key":"e_1_2_9_13_1","unstructured":"Bloddonorerne Danmark. Available from:https:\/\/bloddonor.dk\/. Last accessed 19 Mar 2026."},{"key":"e_1_2_9_14_1","unstructured":"Styrelsen for patientsikkerhed.Rapport over blodproduktomr\u00e5det 2024. Available from:https:\/\/stps.dk\/udgivelser\/2025\/sep\/rapport-over-blodproduktomraadet-2024. Last accessed 19 Mar 2026."},{"key":"e_1_2_9_15_1","unstructured":"Bloddonorerne Danmark.Kendskab\u2010 og donoradf\u00e6rdsm\u00e5ling. 2025. Available from:https:\/\/bloddonor.dk\/fakta-om-blod\/viden-om-donorer\/. Last accessed 12 May 2026."},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healthplace.2020.102495"},{"key":"e_1_2_9_17_1","unstructured":"EU Comission.Regulation \u2010 2024\/1938 \u2010 EN \u2010 EUR\u2010Lex. Available from:https:\/\/eur-lex.europa.eu\/eli\/reg\/2024\/1938\/oj. 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