{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T01:24:31Z","timestamp":1786929871522,"version":"build-2736575974"},"reference-count":4,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T00:00:00Z","timestamp":1786838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T00:00:00Z","timestamp":1786838400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Trans blood donors may be at higher risk of vasovagal reactions (VVRs) if their estimated blood volume is calculated without considering their sex assigned at birth. Yet no studies have addressed this research question. We assessed the rates of VVRs among trans and cisgender blood donors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This was a cross\u2010sectional study of whole blood donors in Qu\u00e9bec, Canada (11 August 2016\u201325 August 2021). Trans donors were identified if they self\u2010reported their gender transition or following an interview triggered by affirmative answers to questions on recent physician consultations and medication use. The odds of VVR were modelled using logistic regression analyses, adjusting for donor age and status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 377,980 donors were included and made 1,799,509 donations: 29 were trans men (mean age\u2009\u00b1\u2009standard deviation [SD]\u2009=\u200928.6\u2009\u00b1\u20099.1), 173,464 were cisgender men (mean age\u2009\u00b1\u2009SD\u2009=\u200942.5\u2009\u00b1\u200916.2), 13 were trans women (mean age\u2009\u00b1\u2009SD\u2009=\u200933.7\u2009\u00b1\u20099.7) and 204,474 were cisgender women (mean age\u2009\u00b1\u2009SD\u2009=\u200938.7\u2009\u00b1\u200915.4). There was no statistically significant difference in the odds of VVR (any severity) between trans and cisgender men (odds ratio [OR] [95% confidence interval, CI]\u2009=\u20091.71 [0.88\u20133.32]) or between trans and cisgender women (OR [95% CI]\u2009=\u20091.33 [0.40\u20134.40]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this study, the risk of VVR was similar among trans and cisgender blood donors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.70348","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:33:21Z","timestamp":1786926801000},"source":"Crossref","is-referenced-by-count":0,"title":["Risk of vasovagal reactions among trans versus cisgender whole blood donors"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1748-4198","authenticated-orcid":false,"given":"Antoine","family":"Lewin","sequence":"first","affiliation":[{"name":"Medical Affairs and Innovation H\u00e9ma\u2010Qu\u00e9bec  Montr\u00e9al Quebec Canada"},{"name":"D\u00e9partement de math\u00e9matiques, Facult\u00e9 des Sciences Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6018-4820","authenticated-orcid":false,"given":"Catherine","family":"Thibeault","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation H\u00e9ma\u2010Qu\u00e9bec  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessyka","family":"Desch\u00eanes","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation H\u00e9ma\u2010Qu\u00e9bec  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Gr\u00e9goire","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation H\u00e9ma\u2010Qu\u00e9bec  Qu\u00e9bec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5685-5380","authenticated-orcid":false,"given":"Christian","family":"Renaud","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation H\u00e9ma\u2010Qu\u00e9bec  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,16]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Statistics Canada\u2010Government of Canada.The Daily\u2014Canada is the first country to provide census data on transgender and non\u2010binary people.2022. Available from:https:\/\/www150.statcan.gc.ca\/n1\/daily-quotidien\/220427\/dq220427b-eng.htm. Last accessed 4 Mar 2026."},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1111\/vox.13299","article-title":"Risk of transfusion\u2010related acute lung injury and human immunodeficiency virus associated with donations from trans donors in Quebec, Canada","volume":"117","author":"Domingue M\u2010P","year":"2022","journal-title":"Vox Sang"},{"key":"e_1_2_9_4_1","first-page":"224","article-title":"Prediction of blood volume in normal human adults","volume":"51","author":"Nadler SB","year":"1962","journal-title":"Surgery"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/trf.18264","article-title":"Deferring blood donors with out\u2010of\u2010range blood pressure: does it decrease the risk of adverse reactions?","volume":"65","author":"Thibeault C","year":"2025","journal-title":"Transfusion"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.70348","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.70348","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.70348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:33:22Z","timestamp":1786926802000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.70348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,16]]},"references-count":4,"alternative-id":["10.1111\/vox.70348"],"URL":"https:\/\/doi.org\/10.1111\/vox.70348","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,16]]},"article-number":"vox.70348"}}