{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:17:10Z","timestamp":1788405430256,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Thalassaemia trait (ThalT), glucose\u20106\u2010phosphate dehydrogenase (G6PD) deficiency and sickle cell trait (SCT) are prevalent inherited red blood cell disorders among blood donors in Italy, particularly in southern and insular regions, and among donors of non\u2010European origin. Despite their frequency, harmonized national guidance on eligibility of carriers for blood and apheresis donation has been lacking, resulting in heterogeneous practices across Italian transfusion centres.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Between 17 January and 16 February 2024, the Italian National Blood Centre distributed a structured questionnaire to 276 transfusion services across the Italian transfusion network. The survey investigated current practices in donor identification, eligibility assessment and blood component utilization for donors with ThalT, G6PD deficiency and SCT. A total of 110 responses (40% response rate) were collected and analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ThalT donors were active in 88% of responding centres; 86 centres (78%) considered individuals with ThalT eligible for whole blood donation, 88 (80%) for plasma apheresis and 40 (36%) for platelet apheresis. G6PD\u2010deficient donors were accepted for whole blood donation in only 19% of centres and for plasma apheresis in 44%. SCT donors were accepted for whole blood in 10% of centres and for plasma apheresis in only 17%. Significant heterogeneity in identification strategies and utilization criteria was observed across all three conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Italian practices are more restrictive than World Health Organization (WHO) and European Directorate for the Quality of Medicines and HealthCare (EDQM) recommendations. Harmonization with international guidelines and targeted haemovigilance monitoring are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.70361","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:45:41Z","timestamp":1787874341000},"source":"Crossref","is-referenced-by-count":0,"title":["Eligibility of blood donors with thalassaemia trait, sickle cell trait or glucose\u20106\u2010phosphate\u2010dehydrogenase deficiency in Italy: Results of a national survey and practical guidance"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7485-803X","authenticated-orcid":false,"given":"Massimo","family":"La Raja","sequence":"first","affiliation":[{"name":"Dipartimento di Medicina Trasfusionale ASUGI University Hospital  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1990-9973","authenticated-orcid":false,"given":"Ursula","family":"La Rocca","sequence":"additional","affiliation":[{"name":"Centro Nazionale Sangue  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9833-1016","authenticated-orcid":false,"given":"Gian Luca","family":"Forni","sequence":"additional","affiliation":[{"name":"Dipartimento di Ematologia Istituto G. Gaslini, Genova, Fondazione Foranemia  Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4264-8459","authenticated-orcid":false,"given":"Giovanni","family":"Garozzo","sequence":"additional","affiliation":[{"name":"Azienda Sanitaria Provinciale 7, Ragusa  Ragusa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro Carmelo","family":"Manca","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera Universitaria di Sassari  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simonetta","family":"Pupella","sequence":"additional","affiliation":[{"name":"Centro Nazionale Sangue  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7214-1561","authenticated-orcid":false,"given":"Luciana","family":"Teofili","sequence":"additional","affiliation":[{"name":"Centro Nazionale Sangue  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.23.291224"},{"key":"e_1_2_9_3_1","first-page":"704","article-title":"Inherited haemoglobin disorders: an increasing global health problem","volume":"79","author":"Weatherall DJ","year":"2001","journal-title":"Bull World Health Organ"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12096"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00273828"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/276761a0"},{"key":"e_1_2_9_7_1","first-page":"875","article-title":"Survey of sickle cell disease in Italy","volume":"83","author":"Russo\u2010Mancuso G","year":"1998","journal-title":"Haematologica"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI133530"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25051"},{"key":"e_1_2_9_10_1","first-page":"289","article-title":"Impact of G6PD status on red cell storage and transfusion outcomes","volume":"17","author":"Karafin MS","year":"2019","journal-title":"Blood Transfus"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.htct.2025.103733"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17021"},{"key":"e_1_2_9_13_1","volume-title":"Blood donor selection: guidelines on assessing donor suitability for blood donation","author":"World Health Organization","year":"2012"},{"key":"e_1_2_9_14_1","volume-title":"Guide to the preparation, use and quality assurance of blood components","author":"European Directorate for the Quality of Medicines & HealthCare (EDQM)","year":"2024"},{"key":"e_1_2_9_15_1","unstructured":"Ministero della Salute.Decreto Ministeriale 2 novembre 2015. 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