{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:53:36Z","timestamp":1791158016135,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016318","name":"Cerus Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016318","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Amotosalen\/ultraviolet A light (A\/UVA) pathogen\u2010reduced platelets and plasma have been approved for clinical use in Europe since 2003 and 2006, respectively. Cross\u2010sectional safety haemovigilance (HV) studies have been conducted in 29 hospitals in 15 European countries since 2003. This report describes the most recent safety and utilization parameters for pathogen\u2010reduced platelets and plasma at three European hospitals between 2019 and 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>All consecutive patients who received at least one A\/UVA platelet or plasma component at participating hospitals in Austria, Poland and Italy were enrolled in a prospective, non\u2010interventional HV study. Patient medical records were reviewed for transfusion reactions (TRs) within 24\u2009h of each transfusion and for serious TRs within 7\u2009days of transfusion. Descriptive per\u2010patient and per\u2010transfusion statistics were calculated for component use and safety variables at each site.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 516 adults received 5331 A\/UVA components. Of these, 475 patients received 3424 platelet components (PCs), 87 patients received 1907 plasma components and 46 patients received both components. Most patients received prophylactic platelet transfusions for haematology\u2010oncology indications. Eight TRs were reported in seven recipients (six TRs in five platelet recipients; two TRs in two plasma recipients). All reactions were non\u2010serious and consisted mainly of febrile non\u2010haemolytic and allergic reactions; one instance of transfusion\u2010associated dyspnoea was reported after platelet transfusion. No transfusion\u2010related acute lung injury (TRALI), transfusion\u2010associated circulatory overload (TACO), transfusion\u2010transmitted infection, transfusion\u2010associated graft\u2010versus\u2010host disease (TA\u2010GVHD)\u00a0or transfusion\u2010related deaths were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A\/UVA platelets and plasma were well tolerated in routine clinical use in three European centres with low TR rates and stable utilization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.70369","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:29:05Z","timestamp":1790299745000},"source":"Crossref","is-referenced-by-count":0,"title":["Prospective multi\u2010centre haemovigilance of amotosalen and\n                    <scp>ultraviolet A<\/scp>\n                    \u2010treated platelets and plasma in routine clinical use"],"prefix":"10.1111","author":[{"given":"Magdalena","family":"\u0141\u0119towska","sequence":"first","affiliation":[{"name":"The Centre of Postgraduate Medical Education  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Krukowska","sequence":"additional","affiliation":[{"name":"Institute of Hematology and Transfusion Medicine  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Piotrowski","sequence":"additional","affiliation":[{"name":"Regional Blood Transfusion Center of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zofia","family":"Przybylska","sequence":"additional","affiliation":[{"name":"Regional Blood Transfusion Center of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Rosskopf","sequence":"additional","affiliation":[{"name":"University Hospital Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8391-7938","authenticated-orcid":false,"given":"Angelo","family":"Ostuni","sequence":"additional","affiliation":[{"name":"Transfusion Medicine, Policlinico Hospital  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Giannoccaro","sequence":"additional","affiliation":[{"name":"Transfusion Medicine, Policlinico Hospital  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Procacci","sequence":"additional","affiliation":[{"name":"Transfusion Medicine, Policlinico Hospital  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Ernst","sequence":"additional","affiliation":[{"name":"Cerus Corporation  Concord California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Irsch","sequence":"additional","affiliation":[{"name":"Cerus Corporation  Concord California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8615-9869","authenticated-orcid":false,"given":"Laurence","family":"Corash","sequence":"additional","affiliation":[{"name":"Cerus Corporation  Concord California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6618-4744","authenticated-orcid":false,"given":"Richard J.","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Cerus Corporation  Concord California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Liu","sequence":"additional","affiliation":[{"name":"Cerus Corporation  Concord California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linh","family":"Dinh","sequence":"additional","affiliation":[{"name":"Cerus Corporation  Concord California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5983-7241","authenticated-orcid":false,"given":"John P.","family":"Pitman","sequence":"additional","affiliation":[{"name":"Cerus Corporation  Concord California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13574"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489900"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.70163"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01643.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2007.01035.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02579.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02151.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15511"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","unstructured":"PrzybylskaZ PiotrowskiD Picard\u2010MaureauM.Pathogen\u2010reduced cryopreserved platelets to maintain 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Gothenburg Sweden Vox Sanguinis 2023: p. 224\u2013225.https:\/\/doi.org\/10.1111\/vox.13433_1","DOI":"10.1111\/vox.13433_1"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12287"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17285"},{"key":"e_1_2_9_13_1","unstructured":"NarayanS.The 2024 annual SHOT report. In Serious Hazards of Transfusion (SHOT) Steering Group (ed). Manchester 2025. Available from:https:\/\/www.shotuk.org\/wp-content\/uploads\/2025\/09\/ANNUAL-SHOT-REPORT-2024-V1.2.pdf. 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Brussels Belgium Official Journal of the European Union 2017. Available from:https:\/\/freepub.edqm.eu\/publications\/PUBSD-240\/detail. 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