{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:47:41Z","timestamp":1792025261387,"version":"4.4.0"},"reference-count":10,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Global demand is rising for human platelet lysate (HPL) in the manufacture of cell\u2010based medicinal products, but platelet resources are scarce. As protocols for the production process and quality testing are heterogeneous, the Working Party on Cellular Therapies of the International Society of Blood Transfusion (ISBT) has recently conducted a survey to obtain information from blood establishments worldwide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      The survey was created at\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/limesurvey.net\">limesurvey.net<\/jats:ext-link>\n                      and consisted of 29 questions on the use of platelet concentrates (PCs) for HPL production to determine the status, conditions, standardization efforts, area of application, and potential difficulties. The link was sent to all ISBT members, and data were analyzed descriptively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 78 participating centers, 12 routinely produce HPL according to in\u2010house protocols, mainly by pooling expired PCs, whereas quality control testing is established in 10 institutions. HPL is used for basic research (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097) and for the manufacture of cell\u2010based medicinal products (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HPL manufacture is still heterogeneous and limited to a few blood centers worldwide. Prospective collaborations between these institutions may contribute to the efforts for international harmonization and consistent regulation of HPL applications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.70392","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:22:44Z","timestamp":1792023764000},"source":"Crossref","is-referenced-by-count":0,"title":["Challenges of human platelet lysate production: Results of an International Survey of the\n                    <scp>ISBT<\/scp>\n                    Working Party on Cellular Therapies"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1416-6023","authenticated-orcid":false,"given":"Sandra","family":"Laner\u2010Plamberger","sequence":"first","affiliation":[{"name":"Department for Transfusion Medicine University Hospital of Salzburg (SALK), Paracelsus Medical University (PMU) Salzburg  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1286-1658","authenticated-orcid":false,"given":"Michaela","family":"Oeller","sequence":"additional","affiliation":[{"name":"Department for Transfusion Medicine University Hospital of Salzburg (SALK), Paracelsus Medical University (PMU) Salzburg  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0507-9243","authenticated-orcid":false,"given":"Thierry","family":"Burnouf","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomaterials and Tissue Engineering College of Biomedical Engineering, Taipei Medical University  Taipei Taiwan"},{"name":"International PhD Program in Biomedical Engineering College of Biomedical Engineering, Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5895-4259","authenticated-orcid":false,"given":"Reinhard","family":"Henschler","sequence":"additional","affiliation":[{"name":"Institute of Transfusion Medicine University Hospital Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7204-0058","authenticated-orcid":false,"given":"Katharina","family":"Schallmoser","sequence":"additional","affiliation":[{"name":"Department for Transfusion Medicine University Hospital of Salzburg (SALK), Paracelsus Medical University (PMU) Salzburg  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1159\/000354061","article-title":"Platelet lysate as replacement for fetal bovine serum in mesenchymal stromal 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from the AABB and the International Society for Cell & Gene Therapy","volume":"21","author":"Bieback K","year":"2019","journal-title":"Cytotherapy"},{"key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/vox.13562","article-title":"Towards standardized human platelet lysate production in Europe: an initiative of the European Blood Alliance","volume":"119","author":"De Korte D","year":"2024","journal-title":"Vox Sang"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tmrv.2019.08.006","article-title":"Is platelet expiring out of date? A systematic review","volume":"34","author":"Flint AWJ","year":"2020","journal-title":"Transfus Med Rev"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-025-04445-9","article-title":"Human platelet lysate standardization across three independent European blood establishments","volume":"16","author":"Delabie W","year":"2025","journal-title":"Stem Cell Res Ther"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.70392","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.70392","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.70392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:22:45Z","timestamp":1792023765000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.70392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,14]]},"references-count":10,"alternative-id":["10.1111\/vox.70392"],"URL":"https:\/\/doi.org\/10.1111\/vox.70392","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,14]]},"article-number":"vox.70392"}}