{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:11:51Z","timestamp":1791227511390,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T00:00:00Z","timestamp":1428883200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G0801971"],"award-info":[{"award-number":["G0801971"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISBT Science Series"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:p>Ten years have passed since the publication of a large focus of <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>lasmodium knowlesi<\/jats:italic> infections in the human population. The discovery was made during a molecular investigation of atypical <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.\u00a0malariae<\/jats:italic> cases in the Kapit Health Division, Sarawak, Malaysian Borneo. Patients were more symptomatic with higher parasite counts than expected in <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.\u00a0malariae<\/jats:italic> infections. The investigation found only <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.\u00a0knowlesi <\/jats:italic><jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> present in patient blood samples. Morphological similarity had allowed <jats:italic>P.\u00a0knowlesi<\/jats:italic> to masquerade as <jats:italic>P.\u00a0malariae<\/jats:italic> during routine diagnostic microscopy for malaria. <jats:italic>P.\u00a0knowlesi<\/jats:italic>, a malaria parasite of macaque monkeys, had entered the human population. The subsequent development of <jats:italic>P.\u00a0knowlesi<\/jats:italic> species\u2010specific <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> assays soon demonstrated that the entry was not confined to the Kapit Division but extended across island and mainland Southeast Asia. Relevant clinical descriptions and guidelines for the treatment and management of patents with <jats:italic>P.\u00a0knowlesi<\/jats:italic> malaria were not available. Nor was it clear whether <jats:italic>P.\u00a0knowlesi<\/jats:italic> had undergone a host switch event into the human population or if infections were zoonotic. The outputs of studies on <jats:italic>P.\u00a0knowlesi<\/jats:italic> malaria during the past 10\u00a0years will be summarized, highlighting major findings within the context of pathophysiology, virulence, host switch events, treatment, control and importantly malaria elimination.<\/jats:p>","DOI":"10.1111\/voxs.12115","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T17:08:36Z","timestamp":1428944916000},"page":"134-140","source":"Crossref","is-referenced-by-count":63,"title":["<i><scp>P<\/scp>lasmodium knowlesi<\/i> \u2013 an emerging pathogen"],"prefix":"10.1111","volume":"10","author":[{"given":"M. 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