{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:23:19Z","timestamp":1787016199737,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T00:00:00Z","timestamp":1468886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISBT Science Series"],"published-print":{"date-parts":[[2016,8]]},"abstract":"\n Background and Objectives<\/jats:title>\n \n Although interest in assessing risk of\n TTI<\/jats:styled-content>\n s, very few trends in blood safety epidemiological data from resource\u2010limited blood services are reported in the literature. This analysis aims at reporting trends in seroprevalences of\n TTI<\/jats:styled-content>\n s in blood donations in the Yaound\u00e9 University Teaching Hospital (\n UTH<\/jats:styled-content>\n ) from 2011 to 2015 and to describe reasons for these changes.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n All donations of 2015 were tested for\n HIV<\/jats:styled-content>\n 1&2 antibodies and the P24 antigen,\n HB<\/jats:styled-content>\n sAg,\n HCV<\/jats:styled-content>\n antibody and the Treponema pallidum antibody. Screening for\n HIV<\/jats:styled-content>\n uses a national algorithm based on the systematic use of two assays of different principles: a rapid determination testing assay and an\n EIA HIV<\/jats:styled-content>\n 1 & 2 Ab\u2010Ag. The tests used for\n HB<\/jats:styled-content>\n sAg and\n HCVA<\/jats:styled-content>\n b screening were all based on\n EIA<\/jats:styled-content>\n techniques. Treponema pallidum antibody screening was based on Treponema Pallidum hemagglutination assay (\n TPHA<\/jats:styled-content>\n ) and rapid immunochromatographic test (\n RIT<\/jats:styled-content>\n ). Screening techniques and results from 2015 were compared to retrospective data from 2011, 2012, 2013 and 2014.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In 2015, 13\u00b74% (\n n<\/jats:italic>\n = 214) of 1,596 blood donations were seropositive for at least one screened\n TTI<\/jats:styled-content>\n s. The most frequent serological marker was\n HB<\/jats:styled-content>\n sAg with 123 (7\u00b77%) blood units contaminated. Nineteen (1\u00b72%) and 18 (1\u00b71%) blood units was positive for\n HIV<\/jats:styled-content>\n and syphilis, respectively. There was a significant decrease in the total number of blood donations (\n P<\/jats:italic>\n < 10\n \u22124<\/jats:sup>\n ) and\n HIV<\/jats:styled-content>\n ,\n HB<\/jats:styled-content>\n sAg and syphilis seroprevalences and an increase in the proportion of voluntary non\u2010remunerated blood donor (\n P<\/jats:italic>\n < 0\u00b705).\n HCVA<\/jats:styled-content>\n b seroprevalence was 3\u00b78% in 2015 and has not decreased significantly over the years (\n P<\/jats:italic>\n = 0\u00b709).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Significant progress is noted in reduction in seroprevalences of\n HIV<\/jats:styled-content>\n ,\n HBV<\/jats:styled-content>\n ,\n HCV<\/jats:styled-content>\n and syphilis since the beginning of a regular registration of data in 1990.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/voxs.12287","type":"journal-article","created":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T03:58:57Z","timestamp":1468900737000},"page":"82-87","source":"Crossref","is-referenced-by-count":9,"title":["Reducing risks of Transfusion\u2010transmitted infections in a resource\u2010limited hospital\u2010based blood bank: the case of the Yaound\u00e9 University Teaching Hospital, Cameroon"],"prefix":"10.1111","volume":"11","author":[{"given":"C. T.","family":"Tagny","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences of University of Yaound\u00e9 I Yaound\u00e9 Cameroon"},{"name":"Hematology & Transfusion Service University Teaching Hospital Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ndoumba","sequence":"additional","affiliation":[{"name":"Hematology & Transfusion Service University Teaching Hospital Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Laperche","sequence":"additional","affiliation":[{"name":"Institut National de la Transfusion Sanguine Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Blood System Research Institute San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Mbanya","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences of University of Yaound\u00e9 I Yaound\u00e9 Cameroon"},{"name":"Hematology & Transfusion Service University Teaching Hospital Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,19]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"49","article-title":"S\u00e9rologie HIV et portage de l'antig\u00e8ne HBs et Hbe chez les donneurs de sang au CHU de Yaound\u00e9. 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