{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T16:05:54Z","timestamp":1750176354390,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,12,28]],"date-time":"2014-12-28T00:00:00Z","timestamp":1419724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:p>Objectives of this prospective study were to describe effects of varying technical components that may contribute to an optimal protocol for computed tomographic pneumocolonography (CTP) in dogs, and to develop a standardized methodology for CTP as a future potential diagnostic tool in canine clinical patients with large bowel disease. Eight purpose\u2010bred intact male hound cross\u2010research dogs were enrolled and randomized to groups based on variables of pressure\/body position (<jats:italic>n<\/jats:italic> = 4) and insufflation time (<jats:italic>n<\/jats:italic> = 4). For each segment of large bowel (rectum, colorectal junction, descending colon, transverse colon, ascending colon), the adequacy of bowel preparation, % of bowel lumen filled with fecal material, and bowel tortuosity or folding were assessed. Measurements of bowel wall thickness (cm), cross\u2010sectional bowel lumen diameter (cm), and cross\u2010sectional bowel luminal area (cm<jats:sup>2<\/jats:sup>) were obtained at standardized locations within the large bowel. False discovery rates (FDR) were calculated to adjust for multiple testing. Values of FDR &lt; 0.05 were considered significant. Differences in mean cross\u2010sectional area and diameter and bowel wall thickness under increasing pressure were not significant after adjusting for multiple testing; some had raw <jats:italic>p<\/jats:italic> values &lt;0.05. Ascending colon diameter and ascending colon area significantly increased with insufflation time (FDR &lt; 0.05). No other response variables showed a significant change with insufflation time. The optimal insufflation pressure for maintaining pneumocolon in this study was determined to be 20 mmHg. CTP is a feasible technique to provide consistent distension for imaging of the large bowel and further study on application of CTP in clinical patients is warranted.<\/jats:p>","DOI":"10.1111\/vru.12235","type":"journal-article","created":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T01:33:53Z","timestamp":1419816833000},"page":"278-285","source":"Crossref","is-referenced-by-count":11,"title":["COMPUTED TOMOGRAPHIC PNEUMOCOLONOGRAPHY IN NORMAL DOGS"],"prefix":"10.1111","volume":"56","author":[{"given":"Michele A.","family":"Steffey","sequence":"first","affiliation":[{"name":"Department of Surgical and Radiological Sciences School of Veterinary Medicine University of California\u2010Davis  Davis CA 95615"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia","family":"Daniel","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences School of Veterinary Medicine University of California\u2010Davis  Davis CA 95615"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra L.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Clinical and Translational Science Center School of Medicine University of California\u2010Davis  Davis CA 95615"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel X.","family":"Chen","sequence":"additional","affiliation":[{"name":"Clinical and Translational Science Center School of Medicine University of California\u2010Davis  Davis CA 95615"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8982-2558","authenticated-orcid":false,"given":"Allison L.","family":"Zwingenberger","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences School of Veterinary Medicine University of California\u2010Davis  Davis CA 95615"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2011.10.030"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2012.05.026"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.216.3.r00au41704"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.3303"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2392052002"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"volume-title":"R: A language and environment for statistical computing","year":"2012","author":"R Core Team","key":"e_1_2_6_8_1"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2012.01969.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(80)73304-7"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(80)90185-7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.145.1.7122864"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1152\/jappl.1996.81.3.1111","article-title":"Transmission of pressure within the abdomen","volume":"81","author":"Tzelepis GE","year":"1996","journal-title":"J Appl Physiol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(86)71876-2"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.2843"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-008-9399-1"},{"key":"e_1_2_6_17_1","first-page":"77","article-title":"Cardiorespiratory and blood gas alterations during laparoscopic surgery for intra\u2010uterine artificial insemination in dogs","volume":"52","author":"Fukushima FB","year":"2011","journal-title":"Can Vet J"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-006-9055-6"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2392050287"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-008-9429-z"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-014-0206-x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2392051374"}],"container-title":["Veterinary Radiology &amp; 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