{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:01:40Z","timestamp":1791378100021,"version":"4.3.2"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T00:00:00Z","timestamp":1444867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>Dexmedetomidine is a highly specific and selective \u03b12\u2010adrenergic receptor agonist widely used in dogs for sedation or analgesia. We hypothesized that dexmedetomidine may cause significant changes in radiographic and echocardiographic measurements. The objective of this prospective cross\u2010sectional study was to test this hypothesis in a sample of six healthy dogs. Staff\u2010owned dogs were recruited and received a single dose of dexmedetomidine 250 \u03bcg\/m<jats:sup>2<\/jats:sup>intravenously. Thoracic radiography and echocardiography were performed 1 h before treatment, and repeated 10 and 30 min after treatment, respectively. One observer recorded cardiac measurements from radiographs and another observer recorded echocardiographic measurements. Vertebral heart score and cardiac size to thorax ratio on the ventrodorsal projection increased from 9.8 \u00b1 0.6 v to 10.3 \u00b1 0.7 v (<jats:italic>P<\/jats:italic>= 0.0007) and 0.61 \u00b1 0.04 to 0.68 \u00b1 0.03 (<jats:italic>P<\/jats:italic>= 0.0109), respectively. E point\u2010to\u2010septal separation and left ventricle internal diameter in diastole and systole increased from 2.4 \u00b1 1.1 to 6.6 \u00b1 1.9 mm, 32.3 \u00b1 8.1 to 35.5 \u00b1 8.8 mm, and 19.4 \u00b1 6 to 27.0 \u00b1 7.2 mm, respectively (<jats:italic>P<\/jats:italic>&lt; 0.05). Fractional shortening and sphericity index decreased from 40.7 \u00b1 5.8 to 24.4 \u00b1 2.9%, and 1.81 \u00b1 0.07 to 1.58 \u00b1 0.04, respectively (<jats:italic>P<\/jats:italic>&lt; 0.05). Moderate\u2010to\u2010severe mitral regurgitation and mild pulmonic regurgitation occurred in all dogs after dexmedetomidine administration. Findings indicated that dexmedetomidine could cause false\u2010positive diagnoses of valvular regurgitation and cardiomegaly in dogs undergoing thoracic radiography and echocardiography.<\/jats:p>","DOI":"10.1111\/vru.12305","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T13:51:58Z","timestamp":1444917118000},"page":"8-15","source":"Crossref","is-referenced-by-count":29,"title":["EFFECTS OF INTRAVENOUS DEXMEDETOMIDINE ON CARDIAC CHARACTERISTICS MEASURED USING RADIOGRAPHY AND ECHOCARDIOGRAPHY IN SIX HEALTHY DOGS"],"prefix":"10.1111","volume":"57","author":[{"given":"Hsien\u2010Chi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine, Veterinary Medical Teaching Hospital, College of Veterinary Medicine National Chung Hsing University Taichung 402 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cih\u2010Ting","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Veterinary Medical Teaching Hospital, College of Veterinary Medicine National Chung Hsing University Taichung 402 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Ming","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Veterinary Medical Teaching Hospital, College of Veterinary Medicine National Chung Hsing University Taichung 402 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui\u2010Ming","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Veterinary Medical Teaching Hospital, College of Veterinary Medicine National Chung Hsing University Taichung 402 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan\u2010Sheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Veterinary Medical Teaching Hospital, College of Veterinary Medicine National Chung Hsing University Taichung 402 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1358\/dof.1993.018.01.198548"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200059020-00012"},{"key":"e_1_2_6_4_1","first-page":"241","article-title":"Distribution and pharmacology of \u03b12\u2010adrenoceptors in the central nervous system","volume":"46","author":"MacDonald E","year":"1995","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00682-7"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.1998.tb00539.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/S0022-3565(25)10402-3","article-title":"Hemodynamic and sedative effects of dexmedetomidine in dog","volume":"263","author":"Bloor BC","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5276.801"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(99)50058-2"},{"key":"e_1_2_6_10_1","first-page":"1","article-title":"FAQs sedation analgesia and anesthesia. 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