{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:21:10Z","timestamp":1787016070348,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,13]],"date-time":"2016-01-13T00:00:00Z","timestamp":1452643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>\n                    Tumors of the nasal cavity comprise approximately 1% of all neoplasms in dogs. Canine intranasal lymphoma is rare and reports evaluating the outcome of treatment are lacking. The goal of this observational, descriptive, multi\u2010institutional study was to evaluate the overall median survival times (MSTs) in a group of dogs with intranasal lymphoma that were treated with irradiation and\/or chemotherapy.\u00a0Dogs meeting these inclusion criteria were retrospectively recruited from medical archives at multiple institutions. Eighteen cases of intermediate to high grade intranasal lymphoma and six cases of low\u2010grade intranasal lymphoma were identified. The date of diagnosis, method of diagnosis, treatment received (radiation and\/or chemotherapy protocols), and date of death were recorded.\u00a0Kaplan\u2013Meier survival analysis was performed on the intermediate to high grade group to calculate overall MST. Log\u2010rank tests were performed to compare effects of treatment with radiation therapy \u00b1 chemotherapy and chemotherapy alone. Kaplan\u2013Meier survival analysis was performed separately on the low\u2010grade group. The overall MST was 375 days for the intermediate to high grade group. Cases treated with radiation \u00b1 chemotherapy had an MST of 455 days (\n                    <jats:italic>n<\/jats:italic>\n                    = 12) and those treated with chemotherapy alone (\n                    <jats:italic>n<\/jats:italic>\n                    = 6) had an MST of 157 days in the intermediate to high grade group. The MST was 823 days for the low\u2010grade group. Results support the use of radiation therapy for treatment of canine intranasal lymphoma, however a randomized, controlled, clinical trial would be needed for more definitive recommendations. The role of adjunctive chemotherapy also may require further investigation.\n                  <\/jats:p>","DOI":"10.1111\/vru.12318","type":"journal-article","created":{"date-parts":[[2016,1,13]],"date-time":"2016-01-13T22:37:26Z","timestamp":1452724646000},"page":"306-312","source":"Crossref","is-referenced-by-count":11,"title":["OUTCOME OF DOGS WITH INTRANASAL LYMPHOMA TREATED WITH VARIOUS RADIATION AND CHEMOTHERAPY PROTOCOLS: 24 CASES"],"prefix":"10.1111","volume":"57","author":[{"given":"Rebecca","family":"George","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Auburn University College of Veterinary Medicine Auburn AL 36849"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Auburn University College of Veterinary Medicine Auburn AL 36849"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Schleis","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Auburn University College of Veterinary Medicine Auburn AL 36849"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Brawner","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Auburn University College of Veterinary Medicine Auburn AL 36849"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Almond","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Auburn University College of Veterinary Medicine Auburn AL 36849"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kent","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences UC Davis School of Veterinary Medicine Davis CA 95616"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie","family":"Wypij","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Illinois College of Veterinary Medicine Urbana\u2010Champaign IL 61802"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Borrego","sequence":"additional","affiliation":[{"name":"Instituto Veterinario de Oncolog\u00eda Comparada (IVOC), Valencia, Espa\u00f1a and University of Wisconsin\u2010Madison School of Veterinary Medicine Madison WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony","family":"Moore","sequence":"additional","affiliation":[{"name":"Veterinary Oncology Consultants Wauchope New South Wales Australia 2446"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Keyerleber","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Tufts University Cummings School of Veterinary Medicine, North Grafton, MA 01536 and Department of Clinical Sciences Cornell University College of Veterinary Medicine Ithaca NY 14853"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Kraiza","sequence":"additional","affiliation":[{"name":"Florida Veterinary Referral Center Estero FL 33928"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2460\/javma.1977.170.01.45","article-title":"Nasal tumors in the dog: retrospective evaluation of diagnosis, prognosis and treatment","volume":"170","author":"MacEwen EG","year":"1977","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"851","DOI":"10.2460\/ajvr.1976.37.07.851","article-title":"Neoplasms of the nasal passages and paranasal sinuses in domesticated animals as reported by 13 veterinary 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