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Stereotactic volumetric modulated arc radiotherapy delivered in a hypofractionated manner allows high doses of radiation to be delivered to the target volume while allowing sparing of adjacent critical structures. This therapy is ideally suited for thymomas in rabbits given their size, the difficulty of multiple anesthesia episodes and the complexity of the radiotherapy plans required due to the tumor's proximity to the heart, lungs, and mediastinal structures. Fifteen rabbits with thymoma were prospectively recruited for this observational, single institution, single arm clinical study. All rabbits were imaged with both computed tomography (CT) and magnetic resonance imaging (MRI). A total dose of 40 Gy in six fractions was delivered using a single arc over an 11\u2010day period with repeat CT simulation done every other fraction for adaptive planning. Follow\u2010up evaluation was done through repeat CT and MRI imaging and revealed complete responses using the Response Evaluation Criteria in Solid Tumors (RECIST) criteria. Two rabbits had died at 618 and 718 days, 10 were alive and three were lost to follow\u2010up. Observed acute and late effects were graded according to the Veterinary Radiation Therapy Oncology Group (VRTOG) criteria and were found to be minimal.<\/jats:p>","DOI":"10.1111\/vru.12321","type":"journal-article","created":{"date-parts":[[2016,1,10]],"date-time":"2016-01-10T12:13:42Z","timestamp":1452428022000},"page":"313-320","source":"Crossref","is-referenced-by-count":22,"title":["FEASIBILITY FOR USING HYPOFRACTIONATED STEREOTACTIC VOLUMETRIC MODULATED ARC RADIOTHERAPY (VMAT) WITH ADAPTIVE PLANNING FOR TREATMENT OF THYMOMA IN RABBITS: 15 CASES"],"prefix":"10.1111","volume":"57","author":[{"given":"Mario","family":"Dolera","sequence":"first","affiliation":[{"name":"La Cittadina Fondazione Studi e Ricerche Veterinarie Strada per la Cittadina 26014 Romanengo (CR) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Malfassi","sequence":"additional","affiliation":[{"name":"La Cittadina Fondazione Studi e Ricerche Veterinarie Strada per la Cittadina 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