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Currently, there is no quantifiable method to tract these pathological changes over time in the horse. The objective of this experimental study was to characterize the progression of MRI changes in an equine model of post\u2010traumatic osteoarthritis using a semiquantitative scoring system for whole\u2010organ evaluation of the middle carpal joint. On day 0, an osteochondral fragment was created in one middle carpal joint (OCI) and the contralateral joint (CON) was sham\u2010operated in 10 horses. On day 14, study horses resumed exercise on a high\u2010speed treadmill until the completion of the study (day 98). High\u2010field MRI examinations were performed on days 0 (preosteochondral fragmentation), 14, and 98 and scored by three blinded observers using consensus agreement. Images were scored based on 15 independent articular features, and scores were compared between and within\u2010groups. On days 14 and 98, OCI joints had significantly (<jats:italic>P<\/jats:italic> \u2264 0.05) higher whole\u2010organ median scores (29.0 and 31.5, respectively), compared to CON joints (21.5 and 20.0, respectively). On day 14, OCI joints showed significant increases in high\u2010signal bone lesion scores, and osteochondral fragment number and size. On day 98, high\u2010signal bone lesion, low\u2010signal bone lesion, osteophyte formation, cartilage signal abnormality, subchondral bone irregularity, joint effusion, and synovial thickening scores were significantly increased in OCI joints. Study results suggest that the MRI whole\u2010organ scoring system reported here may be used to identify onset and progression of pathological changes following osteochondral injury.<\/jats:p>","DOI":"10.1111\/vru.12369","type":"journal-article","created":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T21:34:31Z","timestamp":1463866471000},"page":"502-514","source":"Crossref","is-referenced-by-count":22,"title":["MAGNETIC RESONANCE IMAGING SCORING OF AN EXPERIMENTAL MODEL OF POST\u2010TRAUMATIC OSTEOARTHRITIS IN THE EQUINE CARPUS"],"prefix":"10.1111","volume":"57","author":[{"given":"Andrew D.","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Large Animal Clinical Sciences, University of Florida College of Veterinary Medicine University of Florida  Gainesville FL 32608"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison J.","family":"Morton","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences, University of Florida College of Veterinary Medicine University of Florida  Gainesville FL 32608"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Winter","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, University of Florida College of Veterinary Medicine University of Florida  Gainesville FL 32608"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick T.","family":"Colahan","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences, University of Florida College of Veterinary Medicine University of Florida  Gainesville FL 32608"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Ghivizzani","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, University of Florida College of Medicine Univeristy of Florida  Gainesville FL 32608"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray P.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences, University of Florida College of Veterinary Medicine University of Florida  Gainesville FL 32608"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge A.","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences, University of Florida College of Veterinary Medicine University of Florida  Gainesville FL 32608"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Nickerson","sequence":"additional","affiliation":[{"name":"Department of Statistics University of Central Florida  Orlando FL 32816"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,19]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"KaneAJ. 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