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Objectives of this ex vivo, prospective, methods comparison study were to (1) describe the location and severity of naturally acquired OA lesions in the equine stifle using ultrasound (US), radiography (XR), computed tomography (CT), and macroscopic evaluation (ME); (2) compare the diagnostic performance of each imaging modality with ME; and (3) describe subchondral bone mineral density (BMD) in equine stifle joints with OA using CT. Radiographic, CT, and US evaluations were performed on 23 equine cadaver stifles and compared with ME. Significant associations were found between osteophyte global scores for all imaging modalities (CT,<jats:italic>P<\/jats:italic>\u02c2 0.0001; XR,<jats:italic>P<\/jats:italic>= 0.005; US,<jats:italic>P<\/jats:italic>= 0.04) vs. ME osteophyte global scores. Osteophytes were detected most frequently in the medial femorotibial (MFT) joint. A specific pattern of osteophytes was observed, with a long ridge of new bone at the insertion of the MFT joint capsule cranially on the medial femoral condyle. A novel caudo\u201010\u00b0proximo\u20105\u00b0lateral\u2010cranio\u2010disto\u2010medial oblique radiographic projection was helpful for detection of intercondylar osteophytes. Multiplanar CT reformatted images were helpful for characterizing all osteophytes. Osteophyte grades at most sites did not differ among modalities. Low sensitivity\/specificity for subchondral bone sclerosis and flattening of femoral condyles suggested that these signs may not be reliable radiographic and CT indicators of equine stifle OA. Equine stifle OA was associated with a decrease in BMD and specific sites of focal subchondral bone resorption\/cyst formation were found in some specimens.<\/jats:p>","DOI":"10.1111\/vru.12370","type":"journal-article","created":{"date-parts":[[2016,5,30]],"date-time":"2016-05-30T05:56:43Z","timestamp":1464587803000},"page":"489-501","source":"Crossref","is-referenced-by-count":24,"title":["COMPARISONS AMONG RADIOGRAPHY, ULTRASONOGRAPHY AND COMPUTED TOMOGRAPHY FOR EX VIVO CHARACTERIZATION OF STIFLE OSTEOARTHRITIS IN THE HORSE"],"prefix":"10.1111","volume":"57","author":[{"given":"Julie","family":"De Lasalle","sequence":"first","affiliation":[{"name":"\u00a0Department of Clinical Sciences, Faculty of Veterinary Medicine University of Montreal 3200 Sicotte, PO Box 5000 Saint\u2010Hyacinthe QC Canada"},{"name":"Comparative Orthopedic Research Laboratory, Faculty of Veterinary Medicine University of Montreal 3200 Sicotte, PO Box 5000 Saint\u2010Hyacinthe J2S 7C6, QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Alexander","sequence":"additional","affiliation":[{"name":"\u00a0Department of Clinical Sciences, Faculty of Veterinary Medicine University of Montreal 3200 Sicotte, PO Box 5000 Saint\u2010Hyacinthe QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Olive","sequence":"additional","affiliation":[{"name":"\u00a0Department of Clinical Sciences, Faculty of Veterinary Medicine University of Montreal 3200 Sicotte, PO Box 5000 Saint\u2010Hyacinthe QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Laverty","sequence":"additional","affiliation":[{"name":"\u00a0Department of Clinical Sciences, Faculty of Veterinary Medicine University of Montreal 3200 Sicotte, PO Box 5000 Saint\u2010Hyacinthe QC Canada"},{"name":"Comparative Orthopedic Research Laboratory, Faculty of Veterinary Medicine University of Montreal 3200 Sicotte, PO Box 5000 Saint\u2010Hyacinthe J2S 7C6, QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,30]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"844","volume-title":"Equine surgery","author":"Todhunter RJ","year":"1992"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3292.2001.tb00082.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.04.015"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2746\/0425164044864679"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2005.08.003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.67.3.433"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1302\/2046-3758.111.2000132"},{"key":"e_1_2_8_9_1","volume-title":"Adams and Stashak's lameness in horses. 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