{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:30:41Z","timestamp":1787776241750,"version":"build-2784847793"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T00:00:00Z","timestamp":1475798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>In vivo diagnosis of tick\u2010borne encephalitis is difficult due to high seroprevalence and rapid viral clearance, limiting detection of antibodies in blood and cerebrospinal fluid. Magnetic resonance imaging (MRI) characteristics of tick\u2010borne encephalitis have been reported, however MRI studies can also be negative despite the presence of neurologic signs. Magnetic resonance spectroscopy (<jats:sup>1<\/jats:sup>H MRS) is an imaging method that provides additional information about the metabolic characteristics of brain tissues. The purpose of this retrospective cross\u2010sectional study was to describe brain metabolites using short echo time single\u2010voxel <jats:sup>1<\/jats:sup>H MRS in dogs with confirmed tick\u2010borne encephalitis and compare them with healthy dogs. Inclusion criteria for the affected dogs were neurological symptoms suggestive of tick\u2010borne encephalitis, previous endemic stay and tick\u2010bite, diagnostic quality brain MRI and <jats:sup>1<\/jats:sup>H MRS studies, and positive antibody titers or confirmation of tick\u2010borne encephalitis with necropsy. Control dogs were 10, clinically normal beagles that had been used in a previous study. A total of six affected dogs met inclusion criteria. All dogs affected with tick\u2010borne encephalitis had <jats:sup>1<\/jats:sup>H MRS metabolite concentration alterations versus control dogs. These changes included mild to moderate decreases in N\u2010acetyl aspartate and creatine peaks, and mild increases in glutamate\/glutamine peaks. No lactate or lipid signal was detected in any dog. Myoinositol and choline signals did not differ between affected and control dogs. In conclusion, findings supported the use of <jats:sup>1<\/jats:sup>H MRS as an adjunctive imaging method for dogs with suspected tick\u2010borne encephalitis and inconclusive conventional MRI findings.<\/jats:p>","DOI":"10.1111\/vru.12427","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T04:17:12Z","timestamp":1476332232000},"page":"53-61","source":"Crossref","is-referenced-by-count":15,"title":["COMPARISON BETWEEN PROTON MAGNETIC RESONANCE SPECTROSCOPY FINDINGS IN DOGS WITH TICK\u2010BORNE ENCEPHALITIS AND CLINICALLY NORMAL DOGS"],"prefix":"10.1111","volume":"58","author":[{"given":"Christine","family":"Sievert","sequence":"first","affiliation":[{"name":"Clinic of Diagnostic Imaging, Vetsuisse Faculty University of Zurich  Winterthurerstrasse 258c 8057 Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Richter","sequence":"additional","affiliation":[{"name":"Clinic of Diagnostic Imaging, 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