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Objectives of this retrospective, cross\u2010sectional, methods comparison study were to describe and compare qualitative and quantitative deep phenotypic characteristics of lumbosacral stenosis in Labrador retrievers using computed tomography (CT). Lumbosacral CT scans and medical records were retrieved from data archives at three veterinary hospitals. Using previously published qualitative CT diagnostic criteria, a board\u2010certified veterinary radiologist assigned dogs as either lumbosacral stenosis positive or lumbosacral stenosis negative at six vertebral locations. A second observer independently measured vertebral canal area, vertebral fat area, and vertebral body area; and calculated ratios of vertebral canal area\/vertebral body area and vertebral fat area\/vertebral body area (fat area ratio) at all six locations. Twenty\u2010five dogs were sampled (lumbosacral stenosis negative, 11 dogs; lumbosacral stenosis positive, 14 dogs). Of the six locations, cranial L6 was the most affected by lumbosacral stenosis (33%). Five of six dogs (83%) with clinical signs of lumbosacral pain were lumbosacral stenosis positive at two or more levels. All four quantitative variables were significantly smaller at the cranial aspects of the L6 and L7 vertebral foramina than at the caudal aspects (<jats:italic>P<\/jats:italic>&lt; 0.0001). Fat area ratio was a significant predictor of lumbosacral stenosis positive status at all six locations with cranial L6 having the greatest predictive value (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>= 0.43) and range of predictive probability (25\u201390%). Findings from the current study supported the use of CT as a deep phenotyping tool for future research studies of lumbosacral stenosis in Labrador retrievers.<\/jats:p>","DOI":"10.1111\/vru.12520","type":"journal-article","created":{"date-parts":[[2017,7,10]],"date-time":"2017-07-10T02:54:38Z","timestamp":1499655278000},"page":"565-580","source":"Crossref","is-referenced-by-count":7,"title":["Phenotyping of lumbosacral stenosis in Labrador retrievers using computed tomography"],"prefix":"10.1111","volume":"58","author":[{"given":"Meenakshi","family":"Mukherjee","sequence":"first","affiliation":[{"name":"Department of Animal and Nutritional Sciences, Davis College of Agriculture, Natural Resources, and Design West Virginia University Morgantown WV 26506"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6851-9947","authenticated-orcid":false,"given":"Jeryl C.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Animal and Nutritional Sciences, Davis College of Agriculture, Natural Resources, and Design West Virginia University Morgantown WV 26506"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida","family":"Hol\u00e1skov\u00e1","sequence":"additional","affiliation":[{"name":"Office of Statistics, Davis College of Agriculture, Natural Resources and Design West Virginia University Morgantown WV 26506"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Raylman","sequence":"additional","affiliation":[{"name":"Department of Radiology, Center for Advanced Imaging, Health Sciences West Virginia University Morgantown WV 26506"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Meade","sequence":"additional","affiliation":[{"name":"Cheat Lake Animal Hospital Morgantown WV 26508"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1204453"},{"key":"e_1_2_6_3_1","first-page":"211","volume-title":"Defining psychopathology in the 21st century: DSM\u2010V and beyond","author":"Hudziak JJ","year":"2002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22080"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-008-9071-0"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00133112"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/137.2.380"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109034"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10460"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(88)50062-1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.2460\/javma.1980.177.02.154","article-title":"Lumbosacral stenosis in dogs","volume":"177","author":"Tarvin G","year":"1980","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_6_12_1","first-page":"368","article-title":"Achondroplasia is defined by recurrent G380R mutations of FGFR3","volume":"56","author":"Bellus GA","year":"1995","journal-title":"Am J Hum Gen"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.008334"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.1996.tb01226.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2000.tb00421.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2010.05.006"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/jvet.2003.50001"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.229.12.1924"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.2460\/ajvr.1995.56.09.1125","article-title":"Computed tomographic morphometry of the lumbosacral spine of dogs","volume":"56","author":"Jones JC","year":"1995","journal-title":"Am J Vet Res"},{"key":"e_1_2_6_20_1","unstructured":"SmithS.Most popular dog breeds in America; [cited Febuary 26 2015]. 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