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The aim of this retrospective, case series study was to describe conventional and contrast\u2010enhanced ultrasound (using SonoVue<jats:sup>\u00ae<\/jats:sup>) findings in a group of dogs with histologically confirmed gall bladder disease. A total of 65 dogs were included. Branchlike, heterogeneous, and homogeneous contrast enhancement of echogenic intraluminal mass\u2010forming lesions was a contrast\u2010enhanced ultrasound characteristic of polypoid lesions due to cystic mucosal hyperplasia of the gallbladder and\/or tumor, which had different wash\u2010in and washout characteristics. In dogs with mobile or immobile biliary sludge or mucocele, the echogenic intraluminal masses remained unenhanced. A double rim mark or enhancement defect in the gallbladder wall was a characteristic of edema or necrosis\/rupture of the wall, respectively. Conventional ultrasonography correctly identified biliary sludge or mucocele in 36\/37 dogs, cholecystitis\/edema in 44\/47 dogs, necrosis\/rupture in 19\/25 dogs, and gallbladder neoplasia in three of three dogs with these pathologies. It falsely identified biliary sludge or mucocele in eight of 28 dogs, cholecystitis\/edema in three of 15 dogs, necrosis\/rupture in 13\/37 dogs, and gall\u2010bladder neoplasia in 20\/59 dogs that did not have these pathologies. Contrast\u2010enhanced ultrasound correctly identified cholecystitis\/edema in 42\/47 dogs, but falsely identified cholecystitis\/edema in three of 18 dogs. It correctly identified necrosis\/rupture, benign polypoid lesions, and gallbladder neoplasia in all dogs with no false\u2010positive results. Findings supported contrast\u2010enhanced ultrasound as a complement to conventional ultrasonography for dogs with suspected gallbladder pathologies such as edema, necrosis, and rupture.<\/jats:p>","DOI":"10.1111\/vru.12601","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T10:18:36Z","timestamp":1517566716000},"page":"345-356","source":"Crossref","is-referenced-by-count":19,"title":["Contrast\u2010enhanced ultrasound complements two\u2010dimensional ultrasonography in diagnosing gallbladder diseases in dogs"],"prefix":"10.1111","volume":"59","author":[{"given":"Paolo","family":"Bargellini","sequence":"first","affiliation":[{"name":"Tyrus Clinica Veterinaria  05100 Terni Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Orlandi","sequence":"additional","affiliation":[{"name":"Tyrus Clinica Veterinaria  05100 Terni Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Paloni","sequence":"additional","affiliation":[{"name":"Tyrus Clinica Veterinaria  05100 Terni Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Rubini","sequence":"additional","affiliation":[{"name":"Ultravet Diagnostic  40017 Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Fonti","sequence":"additional","affiliation":[{"name":"Centro Veterinario Specialistico  00137 Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Righi","sequence":"additional","affiliation":[{"name":"Dipartimento di Diagnostica Generale e Benessere Animale Istituto Zooprofilattico Sperimentale dell'Umbria e della Marche  06126 Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3016-1855","authenticated-orcid":false,"given":"Mark E.","family":"Peterson","sequence":"additional","affiliation":[{"name":"Endocrinology &amp; 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