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It was hypothesized that enhanced glucose uptake, as measured by 2\u2010[fluorine\u201018]fluoro\u2010<jats:sc>d<\/jats:sc>\u2010glucose\u2010positron emission tomography\/computed tomography (F18 FDG PET\u2010CT), would correlate with histologic grade. Dogs were recruited for this study from a population referred for treatment of cytologically or histologically confirmed mast cell tumors. Patients were staged utilizing standard of care methods (abdominal ultrasound and three view thoracic radiographs), followed by a whole body F18 FDG PET\u2010CT. Results of the F18 FDG PET\u2010CT were analyzed for possible metastasis and standard uptake value maximum (SUV<jats:sub>max<\/jats:sub>) of identified lesions. Incisional or excisional biopsies of the accessible mast cell tumors were obtained and histology performed. Results were then analyzed to look for a possible correlation between the grade of mast cell tumors and SUV<jats:sub>max<\/jats:sub>. A total of nine animals were included in the sample. Findings indicated that there was a correlation between grade of mast cell tumors and SUV<jats:sub>max<\/jats:sub> as determined by F18 FDG PET\u2010CT (<jats:italic>p<\/jats:italic>\u2010value\u00a0=\u00a00.073, significance \u2264\u00a00.1). Based on the limited power of this study, it is felt that further research to examine the relationship between glucose utilization and biologic aggressiveness in canine mast cell tumors is warranted. This study was unable to show that F18 FDG PET\u2010CT was a better staging tool than standard of care methods.<\/jats:p>","DOI":"10.1111\/vru.12612","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T13:57:49Z","timestamp":1521813469000},"page":"461-468","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Pilot study utilizing Fluorine\u201018 fluorodeoxyglucose\u2010positron emission tomography\/computed tomography for glycolytic phenotyping of canine mast cell tumors"],"prefix":"10.1111","volume":"59","author":[{"given":"Lynn R.","family":"Griffin","sequence":"first","affiliation":[{"name":"Department of Environmental and Radiological Health Sciences (ERHS) Colorado State University  Fort Collins CO 80523"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doug H.","family":"Thamm","sequence":"additional","affiliation":[{"name":"Flint Animal Cancer Center (FACC) 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