{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:49:12Z","timestamp":1789685352338,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T00:00:00Z","timestamp":1525824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Scintigraphy is a standard diagnostic method for evaluating horses with back pain due to suspected thoracic processus spinosus pathology. Lesion detection is based on subjective or semi\u2010quantitative assessments of increased uptake. This retrospective, analytical study is aimed to compare semi\u2010quantitative and subjective methods in the evaluation of scintigraphic images of the processi spinosi in the equine thoracic spine. Scintigraphic images of 20 Warmblood horses, presented for assessment of orthopedic conditions between 2014 and 2016, were included in the study. Randomized, blinded image evaluation was performed by 11 veterinarians using subjective and semi\u2010quantitative methods. Subjective grading was performed for the analysis of red\u2010green\u2010blue and grayscale scintigraphic images, which were presented in full\u2010size or as masked images. For the semi\u2010quantitative assessment, observers placed regions of interest over each processus spinosus. The uptake ratio of each processus spinosus in comparison to a reference region of interest was determined. Subsequently, a modified semi\u2010quantitative calculation was developed whereby only the highest counts\u2010per\u2010pixel for a specified number of pixels was processed. Inter\u2010 and intraobserver agreement was calculated using intraclass correlation coefficients. Inter\u2010 and intraobserver intraclass correlation coefficients were 41.65% and 71.39%, respectively, for the subjective image assessment. Additionally, a correlation between intraobserver agreement, experience, and grayscale images was identified. The inter\u2010 and intraobserver agreement was significantly increased when using semi\u2010quantitative analysis (97.35% and 98.36%, respectively) or the modified semi\u2010quantitative calculation (98.61% and 98.82%, respectively). The proposed modified semi\u2010quantitative technique showed a higher inter\u2010 and intraobserver agreement when compared to other methods, which makes it a useful tool for the analysis of scintigraphic images. The association of the findings from this study with clinical and radiological examinations requires further investigation.<\/jats:p>","DOI":"10.1111\/vru.12621","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T14:26:53Z","timestamp":1525876013000},"page":"469-476","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Semi\u2010quantitative methods yield greater inter\u2010 and intraobserver agreement than subjective methods for interpreting\n                    <sup>99m<\/sup>\n                    technetium\u2010hydroxymethylene\u2010diphosphonate uptake in equine thoracic processi spinosi"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1403-8638","authenticated-orcid":false,"given":"Claudia","family":"van Zadelhoff","sequence":"first","affiliation":[{"name":"Equine Clinic Free University of Berlin Berlin Germany"},{"name":"Pferdeklinik Bargteheide Bargteheide Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Ehrle","sequence":"additional","affiliation":[{"name":"Equine Clinic Free University of Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roswitha","family":"Merle","sequence":"additional","affiliation":[{"name":"Institute for Veterinary Epidemiology and Biostatistics Free University of Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Jahn","sequence":"additional","affiliation":[{"name":"Pferdeklinik Bargteheide Bargteheide Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Lischer","sequence":"additional","affiliation":[{"name":"Equine Clinic Free University of Berlin Berlin 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