{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:29:45Z","timestamp":1787776185955,"version":"build-2784847793"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,6,10]],"date-time":"2018-06-10T00:00:00Z","timestamp":1528588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Mississippi State University College of Veterinary Medicine - Department of Clinical Sciences","award":["290010-184105-031000 - Gambino"],"award-info":[{"award-number":["290010-184105-031000 - Gambino"]}]},{"name":"The American College of Veterinary Radiology CT\/MRI Society","award":["0012205063"],"award-info":[{"award-number":["0012205063"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Conventional magnetic resonance imaging (MRI) characteristics of canine brain diseases are often nonspecific. Single\u2010 and multi\u2010voxel spectroscopy techniques allow quantification of chemical biomarkers for tissues of interest and may help to improve diagnostic specificity. However, published information is currently lacking for the in vivo performance of these two techniques in dogs. The aim of this prospective, methods comparison study was to compare the performance of single\u2010 and multi\u2010voxel spectroscopy in the brains of eight healthy, juvenile dogs using 3 Tesla MRI. Ipsilateral regions of single\u2010 and multi\u2010voxel spectroscopy were performed in symmetric regions of interest of each brain in the parietal (<jats:italic>n<\/jats:italic>\u00a0=\u00a03), thalamic (<jats:italic>n<\/jats:italic>\u00a0=\u00a02), and piriform lobes (<jats:italic>n<\/jats:italic>\u00a0=\u00a03). In vivo single\u2010voxel spectroscopy and multi\u2010voxel spectroscopy metabolite ratios from the same size and multi\u2010voxel spectroscopy ratios from different sized regions of interest were compared. No significant difference was seen between single\u2010voxel spectroscopy and multi\u2010voxel spectroscopy metabolite ratios for any lobe when regions of interest were similar in size and shape. Significant lobar single\u2010voxel spectroscopy and multi\u2010voxel spectroscopy differences were seen between the parietal lobe and thalamus (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.047) for the choline to <jats:italic>N\u2010<\/jats:italic>acetyl aspartase ratios when large multi\u2010voxel spectroscopy regions of interest were compared to very small multi\u2010voxel spectroscopy regions of interest within the same lobe; and for the <jats:italic>N\u2010<\/jats:italic>acetyl aspartase to creatine ratios in all lobes when single\u2010voxel spectroscopy was compared to combined (pooled) multi\u2010voxel spectroscopy datasets. Findings from this preliminary study indicated that single\u2010 and multi\u2010voxel spectroscopy techniques using 3T MRI yield comparable results for similar sized regions of interest in the normal canine brain. Findings also supported using the contralateral side as an internal control for dogs with brain lesions.<\/jats:p>","DOI":"10.1111\/vru.12634","type":"journal-article","created":{"date-parts":[[2018,6,10]],"date-time":"2018-06-10T22:07:01Z","timestamp":1528668421000},"page":"577-586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Single\u2010voxel and multi\u2010voxel spectroscopy yield comparable results in the normal juvenile canine brain when using 3 Tesla magnetic resonance imaging"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4452-1935","authenticated-orcid":false,"given":"Alison M.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Mississippi State University College of Veterinary Medicine  Mississippi State MS 39762"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela 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