{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:24:15Z","timestamp":1787016255317,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T00:00:00Z","timestamp":1557100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Vertebral lesions and associated neurological signs occur in dogs with multiple myeloma, however, veterinary literature describing MRI findings is currently lacking. The objective of this multicenter, retrospective, case series study was to describe neurological signs and MRI findings in a group of dogs that presented for spinal pain or other neurological deficits and had multiple myeloma. Electronic records of four veterinary referral hospitals were reviewed. Dogs were included if they had a pathologically confirmed diagnosis of multiple myeloma, had presented for spinal pain or other neurological signs, and had undergone MRI of the vertebral column. The MRI studies were evaluated and the anatomical location of lesion(s), signal intensity, presence of extra\u2010dural material, degree of spinal cord compression, extent of vertebral lesions, and contrast enhancement were recorded. Twelve dogs met inclusion criteria. Most dogs (n\u00a0=\u00a08) had a chronic progressive history, with varying degrees of proprioceptive ataxia and paresis (n\u00a0=\u00a011), and spinal pain was a feature in all dogs. The MRI findings were variable but more consistent features included the presence of multiple expansile vertebral lesions without extension beyond the outer cortical limits of affected vertebrae, and associated extradural material causing spinal cord compression. The majority of lesions were hyper\u2010 to isointense on T2 (n\u00a0=\u00a012) and T1\u2010weighted (n\u00a0=\u00a08) sequences, with variable but homogeneous contrast\u2010enhancement (n\u00a0=\u00a012). These described MRI characteristics of multiple myeloma may be used to aid early identification and guide subsequent confirmatory diagnostic steps, to ultimately improve therapeutic approach and long\u2010term outcome.<\/jats:p>","DOI":"10.1111\/vru.12759","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T15:51:26Z","timestamp":1557157886000},"page":"409-415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Neurological signs and MRI findings in 12 dogs with multiple myeloma"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0509-247X","authenticated-orcid":false,"given":"Sophie","family":"Wyatt","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Science and Services Royal Veterinary College University of London  Hatfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"De Risio","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery Animal Health Trust  Newmarket UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Driver","sequence":"additional","affiliation":[{"name":"Fitzpatrick Referrals  Eashing UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Jos\u00e9\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Pivetta","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Science and Services Royal Veterinary College University of London  Hatfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0807-7817","authenticated-orcid":false,"given":"Elsa","family":"Beltran","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Science and Services Royal Veterinary College University of London  Hatfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,6]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"665","volume-title":"Small Animal Clinical Oncology","author":"Vail DM","year":"2013"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1999.tb01140.x"},{"key":"e_1_2_8_4_1","first-page":"2075","volume-title":"Textbook of Veterinary Internal Medicine","author":"Vail DM","year":"2017"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-0279(77)50010-X"},{"key":"e_1_2_8_6_1","first-page":"1288","article-title":"Prognostic factors for multiple myeloma in the dog","volume":"188","author":"Matus RE","year":"1986","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.1999.tb00890.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.4142\/jvs.2016.17.2.225"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.89"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.57.9961"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2005.01.017"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.1980.tb01684.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.185.3.1438772"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12149"},{"key":"e_1_2_8_15_1","first-page":"1949","volume-title":"Textbook of Veterinary Internal Medicine","author":"Polzin DJ","year":"2017"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2010.01756.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1214160"},{"key":"e_1_2_8_18_1","unstructured":"PetrovitchNP RobertsonID MarianiCL OlbyNJ SeilerGS.Relative T1 hyperintensity of solitary osseous vertebral plasmacytomas when compared to other vertebral tumors. Abstract presented at: Annual Conference of the American College of Veterinary Radiology2016; October 19\u201022 2016; Orlando USA."},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.70"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi362"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12359"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118940372.ch15"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1977.tb05890.x"},{"key":"e_1_2_8_24_1","first-page":"1300","article-title":"Multiple myeloma in the dog","volume":"153","author":"Osborne C","year":"1968","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13509"}],"container-title":["Veterinary Radiology &amp; Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vru.12759","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vru.12759","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vru.12759","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T10:23:14Z","timestamp":1694341394000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vru.12759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,6]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1111\/vru.12759"],"URL":"https:\/\/doi.org\/10.1111\/vru.12759","archive":["Portico"],"relation":{},"ISSN":["1058-8183","1740-8261"],"issn-type":[{"value":"1058-8183","type":"print"},{"value":"1740-8261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,6]]},"assertion":[{"value":"2018-10-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}