{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T20:20:47Z","timestamp":1771618847988,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T00:00:00Z","timestamp":1570665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["320030\u2010182490"],"award-info":[{"award-number":["320030\u2010182490"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Irradiated brain tumors commonly progress at the primary site, generating interest in focal dose escalation. The aim of this retrospective observational study was to use biological optimization objectives for a modeling exercise with simultaneously\u2010integrated boost IMRT (SIB\u2010IMRT) to generate a dose\u2010escalated protocol with acceptable late radiation toxicity risk estimate and improve tumor control for brainstem tumors in dogs safely. We re\u2010planned 20 dog brainstem tumor datasets with SIB\u2010IMRT, prescribing 20\u00a0\u00d7\u00a02.81\u00a0Gy to the gross tumor volume (GTV) and 20\u00a0\u00d7\u00a02.5\u00a0Gy to the planning target volume. During the optimization process, we used biologically equivalent generalized equivalent uniform doses (gEUD) as planning aids. These were derived from human data, calculated to adhere to normal tissue complication probability (NTCP) \u22645%, and converted to the herein used fractionation schedule. We extracted the absolute organ at risk dose\u2010volume histograms to calculate NTCP of each individual plan. For planning optimization, gEUD<jats:sub>(a = 4)\u00a0<\/jats:sub>=\u00a039.8\u00a0Gy for brain and gEUD<jats:sub>(a = 6.3)\u00a0<\/jats:sub>=\u00a043.8\u00a0Gy for brainstem were applied. Mean brain NTCP was low with 0.43% (SD \u00b10.49%, range 0.01\u20102.04%); mean brainstem NTCP was higher with 7.18% (SD \u00b14.29%, range 2.87\u201020.72%). Nevertheless, NTCP of\u00a0&lt;\u00a010% in brainstem was achievable in 80% (16\/20) of dogs. Spearman's correlation between relative GTV and NTCP was high (\u03c1\u00a0=\u00a00.798,<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), emphasizing increased risk with relative size even with subvolume\u2010boost. Including biologically based gEUD values into optimization allowed estimating NTCP during the planning process. In conclusion, gEUD\u2010based SIB\u2010IMRT planning resulted in dose\u2010escalated treatment plans with acceptable risk estimate of NTCP\u00a0&lt;\u00a010% in the majority of dogs with brainstem tumors. Risk was correlated with relative tumor size.<\/jats:p>","DOI":"10.1111\/vru.12815","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T19:39:23Z","timestamp":1570736363000},"page":"77-84","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Using biologically based objectives to optimize boost intensity\u2010modulated radiation therapy planning for brainstem tumors in dogs"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0793-9005","authenticated-orcid":false,"given":"Valeria","family":"Meier","sequence":"first","affiliation":[{"name":"Division of Radiation Oncology, Small Animal Department, Vetsuisse Faculty University of Zurich Zurich Switzerland"},{"name":"Department of Physics University of Zurich Zurich 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