{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:24:24Z","timestamp":1790198664028,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Contrast\u2010enhanced voiding urosonography (CE\u2010VUS) has been generally considered as a promising tool to diagnose vesicoureteral reflux and abnormalities in lower urinary tract in human patients, especially in children. The purpose of this prospective study is to evaluate the quality of images of the urinary bladder and urethra obtained by CE\u2010VUS using a second\u2010generation ultrasound contrast agent (SonoVue\u00ae) in healthy dogs and to investigate the safety profile of SonoVue\u00ae after intravesical administration. Eighty\u2010four CE\u2010VUS examinations with SonoVue\u00ae were successfully performed in both unsedated (39\/84) and sedated (45\/84) dogs. Contrast\u2010enhanced voiding urosonography examination of urinary bladder was technically successful in all (84\/84) dogs. The image quality was not considered adequate in five (5\/84) dogs including three dogs in whom layering of contrast media during filling phase was observed and two dogs with premature destruction of microbubbles. In these five dogs, the problem was readily recognized and corrected such that the procedure was still successfully undertaken. The assessment of the urethra during spontaneous micturition was successfully performed in all (84\/84) dogs in whom voiding was elicited during the examination. No side effects were observed after intravesical application of SonoVue\u00ae. This study demonstrates that CE\u2010VUS is a feasible and valuable technique to evaluate low urinary tract morphology and function in dogs. Based on our review of the literature, there are no published reports about the use of this method in dogs.<\/jats:p>","DOI":"10.1111\/vru.12867","type":"journal-article","created":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T03:58:38Z","timestamp":1590638318000},"page":"453-460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Contrast\u2010enhanced voiding urosonography: A new, radiation\u2010free, alternative method for imaging of urinary bladder and urethra in healthy dogs"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5749-5345","authenticated-orcid":false,"given":"Georgia","family":"Trikoupi","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine Aristotle University of Thessaloniki  Stavrou Voutira Thessaloniki 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