{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:49:14Z","timestamp":1789685354348,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T00:00:00Z","timestamp":1602374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This prospective, cross\u2010sectional, pilot study aimed to investigate the effects of furosemide as a diuretic\u00a0on the image quality of bone scintigraphy performed using <jats:sup>99m<\/jats:sup>Tc\u2010HDP and to investigate the impact of furosemide on the radiation dose rate. Thirty\u2010one horses undergoing bone scintigraphy were included. The horses were divided into the control (n\u00a0=\u00a014) and furosemide group (n\u00a0=\u00a017), which received 1\u00a0mg\/kg furosemide intravenously 1 h post <jats:sup>99m<\/jats:sup>Tc\u2010HDP administration. The image quality was assessed subjectively and semi\u2010quantitatively. The bone\u2010to\u2010soft tissue (B:S) ratio was calculated from the counts per pixel of regions of interest (ROI) positioned over the left radial diaphysis (bone ROI) and its caudal soft tissue area (soft tissue ROI). The radiation rate dose (\u03bcSv\/h) of both groups was measured at 0, 3, 6, 12, 18, and 24\u00a0h post <jats:sup>99m<\/jats:sup>Tc\u2010HDP administration at a distance of 0, 30, and 100\u00a0cm from the head, kidney, and pelvis. The results showed no significant differences in the B:S ratio or the radiation dose rate observed between the groups. However, the radiation dose rate decreased by 56% at 3\u00a0h post <jats:sup>99m<\/jats:sup>Tc\u2010HDP administration and keeping a distance of 30\u00a0cm reduced the radiation dose rate by 65%. Administering furosemide does not improve the image quality or reduce the radiation dose rate. The authors recommend commencing with bone scintigraphy 3\u00a0h post <jats:sup>99m<\/jats:sup>Tc\u2010HDP administration and keeping at least a distance of 30\u00a0cm from the horse to reduce the staff radiation dose.<\/jats:p>","DOI":"10.1111\/vru.12917","type":"journal-article","created":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T14:49:41Z","timestamp":1602427781000},"page":"126-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Furosemide administration onehour before bone scintigraphy examination in horses does not improve the image quality or reduce the radiation dose rate"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2686-0407","authenticated-orcid":false,"given":"Mahmoud","family":"Mageed","sequence":"first","affiliation":[{"name":"Tierklinik L\u00fcsche GmbH Tierklinik L\u00fcsche GmbH  Essenerstr. 39a, Bakum, 49456 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Wegert","sequence":"additional","affiliation":[{"name":"Tierklinik L\u00fcsche GmbH Tierklinik L\u00fcsche GmbH  Essenerstr. 39a, Bakum, 49456 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahlaa","family":"Dyab","sequence":"additional","affiliation":[{"name":"Tierklinik L\u00fcsche GmbH Tierklinik L\u00fcsche GmbH  Essenerstr. 39a, Bakum, 49456 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Gerlach","sequence":"additional","affiliation":[{"name":"Departement for Horses University of Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0739(17)30075-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-016-3415-4"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.102104"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00252942"},{"key":"e_1_2_9_6_1","first-page":"427","article-title":"Influence of the phosphate balance on the activity distribution of 99mTc\u2010hydroxy\u2010methylene diphosphonate: experimental studies in the mouse","volume":"39","author":"Cronhjort M","year":"1998","journal-title":"Acta radiol"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-199907000-00002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9619.1000384"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-199710000-00007"},{"key":"e_1_2_9_10_1","first-page":"101","article-title":"Interaction between 99Tcm\u2010hydroxymethylene diphosphonate and loop\u2010diuretics in an experimental mouse system","volume":"35","author":"Cronhjort M","year":"1994","journal-title":"Radiol Diagnost"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.2012.01145.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2004.tb02614.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2005.00097.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2003.tb00534.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.105459"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1991.tb00951.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(95)80027-1"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-199406000-00012"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2010.00301.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2006.tb05547.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11259-010-9413-2"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2010.12.011"},{"key":"e_1_2_9_23_1","unstructured":"ErichsenC AndersenH LonningM BjornstadA EksellP Will furosemide administrated to the horse prior to scintigraphy examinations reduce the radiation rate dose.http:\/\/equirad.no\/wpcontent\/uploads\/2011\/04\/2007_F. 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