{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T07:14:49Z","timestamp":1768288489778,"version":"3.49.0"},"reference-count":7,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012752","name":"Elanco Animal Health","doi-asserted-by":"publisher","award":["CHE\u20101708844"],"award-info":[{"award-number":["CHE\u20101708844"]}],"id":[{"id":"10.13039\/100012752","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This prospective exploratory study aimed to determine whether certain noninvasive advanced imaging techniques could estimate parasitic burden in heartworm\u2010infested dogs; a noninvasive method is needed for ethical considerations and permitting longitudinal drug studies. Three cardiac\u2010gated and respiratory\u2010gated 3T MRI techniques and CT pulmonary angiography (CTPA) were performed in three healthy beagles to optimize imaging techniques. Once the imaging techniques were established, a pilot study was performed to determine which one of the MRI techniques would be used in an observer comparison study. Ultimately, spoiled gradient recalled (SPGR)\u2010cine\u2010MRI and CTPA were performed in four and five heartworm\u2010infested dogs, respectively. Heartworms were detected in the pulmonary arteries in all dogs during SPGR\u2010cine\u2010MRI and in no dog during CTPA. However, counting the number of worms was unsuccessful. In conclusion, CTPA and SPGR\u2010cine\u2010MRI were unable to replace necropsy for quantifying parasitic burden in heartworm\u2010infested dogs.<\/jats:p>","DOI":"10.1111\/vru.12945","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T22:35:30Z","timestamp":1608676530000},"page":"471-475","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Selected advanced imaging techniques were unable to quantify in vivo parasitic burden in heartworm\u2010infested dogs"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3967-2405","authenticated-orcid":false,"given":"Assaf","family":"Lerer","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Department of Clinical Sciences Cornell University  Ithaca New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dwight D.","family":"Bowman","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Department of Microbiology and Immunology Cornell University  Ithaca New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Ming","family":"Luh","sequence":"additional","affiliation":[{"name":"Cornell MRI Facility Cornell University  Ithaca New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameon M.","family":"Ohmes","sequence":"additional","affiliation":[{"name":"Elanco Animal Health  Shawnee Kansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter V.","family":"Scrivani","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Department of Clinical Sciences Cornell University  Ithaca New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"American Heartworm Society.2018.Our vision: A world without heartworms.https:\/\/www.heartwormsociety.org. 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