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The objective of this retrospective, multicenter, cross\u2010sectional study is to describe the clinical, ultrasonographic, and CT features of pleural and peritoneal carcinomatosis and sarcomatosis in dogs and cats to aid detection and differentiation of these lesions. Medical records and CT and ultrasonographic images were reviewed. Although a large degree of overlap was observed between the imaging features and clinical signs of canine and feline carcinomatosis and sarcomatosis, some distinguishing features were observed. Dogs were significantly more likely to present with abdominal pain compared to cats (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.022), whereas cats more commonly presented with inappetence (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.019). Dogs with sarcomatosis had a significantly heavier bodyweight than dogs with carcinomatosis (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.005), largely due to a higher prevalence of splenic hemangiosarcoma in this patient cohort. Peritoneal effusion was more frequently observed in dogs with carcinomatosis compared to dogs with sarcomatosis (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.021). Imaging and clinical features observed in this study may help to distinguish sarcomatosis and carcinomatosis lesions. Due to the large degree of overlap observed, cytological or histopathological analysis is recommended for definitive diagnosis.<\/jats:p>","DOI":"10.1111\/vru.12951","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T19:06:05Z","timestamp":1611255965000},"page":"331-341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Clinical, CT, and ultrasonographic features of canine and feline pleural and peritoneal carcinomatosis and sarcomatosis"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1616-7625","authenticated-orcid":false,"given":"Philippa J","family":"Weston","sequence":"first","affiliation":[{"name":"Willows Referral Centre  Solihull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J","family":"Baines","sequence":"additional","affiliation":[{"name":"Willows Referral Centre  Solihull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1932-211X","authenticated-orcid":false,"given":"Riccardo","family":"Finotello","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Science, Institute of Infection, Veterinary and Ecological Science University of Liverpool  Neston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy R","family":"Mortier","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Science, Institute of Infection, Veterinary and Ecological Science University of Liverpool  Neston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"299","volume-title":"Disorders of cell growth and cancer biology","author":"Cockerell GL","year":"2002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5810.2005.00075.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2014.06.019"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2011.639056"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2004.04096.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12394"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-6227"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2007.00339.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2009.00850.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12615"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1991.tb00953.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1993.tb01033.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.3907"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12431"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.1971.tb00402.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2011.01883.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12706"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12534"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.201.2.8888239"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2007.00320.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2010.01675.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-5750"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12075"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12240"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.292085189"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.12.6.1439011"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2012.00320.x"},{"key":"e_1_2_7_29_1","first-page":"2729","volume-title":"Cancer Principles and Practice of Oncology","author":"Schrump D","year":"2001"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012504904713"},{"key":"e_1_2_7_31_1","first-page":"706","article-title":"Epidemiologic, clinical, pathologic, and prognostic characteristics of splenic hemangiosarcoma and splenic hematoma in dogs: 217 cases (1985)","volume":"193","author":"Prymak C","year":"1988","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12709"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15099"},{"key":"e_1_2_7_34_1","unstructured":"WithrowS PageR VailD Withrow and MacEwen's Small Animal Clinical Oncology. 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