{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T23:49:58Z","timestamp":1768261798411,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two\u2010dimensional shear wave elastography (2D\u2010SWE) can be used to quantitatively evaluate the elastic modulus of the liver as shear wave velocity (SWV), which can noninvasively predict clinically relevant hepatic fibrosis in both dogs and humans. However, extrahepatic biliary obstruction (EHBO), regardless of the presence of clinically relevant hepatic fibrosis, can influence SWVs in humans and thus may interfere with hepatic fibrosis prediction using 2D\u2010SWE in dogs. The aim of this prospective, observational, and one\u2010group pretest\u2013posttest study is to investigate whether SWV measured by 2D\u2010SWE displays a difference between dogs with and without EHBO. A total of 20 dogs were included (7 with EHBO and 13 with gallbladder pathology but no EHBO) that underwent preoperative SWV measurement using 2D\u2010SWE. In all dogs, stages of hepatic fibrosis were evaluated histopathologically using a scoring scheme. In addition, postoperative SWVs in dogs with EHBO relieved via laparotomy were also evaluated. The median (range) SWVs in the dogs with and without EHBO were 1.91 (1.81\u20132.54) m\/s and 1.57 (1.37\u20131.64) m\/s, respectively. Although there was no significant difference in the histopathological hepatic fibrosis stages between the dogs with and without EHBO, the preoperative SWVs in the dogs with EHBO were significantly higher than in dogs without EHBO (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0004), and SWVs were found to decrease significantly after surgery (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0097). This study demonstrates that EHBO can increase the SWV of dogs without clinically relevant hepatic fibrosis and can interfere with the prediction of noninvasive hepatic fibrosis using 2D\u2010SWE.<\/jats:p>","DOI":"10.1111\/vru.12969","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T20:42:37Z","timestamp":1618519357000},"page":"483-489","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Extrahepatic biliary obstruction can interfere with hepatic fibrosis prediction using two\u2010dimensional shear wave elastography in dogs"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9721-304X","authenticated-orcid":false,"given":"Masahiro","family":"Tamura","sequence":"first","affiliation":[{"name":"Veterinary Teaching Hospital, Graduate school of Veterinary Medicine Hokkaido University  Sapporo Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3673-4319","authenticated-orcid":false,"given":"Hiroshi","family":"Ohta","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine Hokkaido University  Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuyuki","family":"Osuga","sequence":"additional","affiliation":[{"name":"Veterinary Teaching Hospital, Graduate school of Veterinary Medicine Hokkaido University  Sapporo Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine Hokkaido University  Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keitaro","family":"Morishita","sequence":"additional","affiliation":[{"name":"Veterinary Teaching Hospital, Graduate school of Veterinary Medicine Hokkaido University  Sapporo Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7648-7036","authenticated-orcid":false,"given":"Mitsuyoshi","family":"Takiguchi","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine Hokkaido University  Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2015.03.007"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.18650"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20506"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i23.2918"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i39.11077"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15598"},{"key":"e_1_2_9_8_1","first-page":"214","volume-title":"Textbook of Veterinary Internal Medicine","author":"Ettinger SJ","year":"2017"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22577"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2011.00797.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2014.02.020"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-4867-1.00009-X"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.80.4.378"},{"key":"e_1_2_9_14_1","first-page":"61","volume-title":"Standards for Clinical and Histological Diagnosis of Canine and Feline Liver Diseases","author":"WSAVA Liver Standardization Group","year":"2006"},{"key":"e_1_2_9_15_1","first-page":"85","volume-title":"Standards for Clinical and Histological Diagnosis of Canine and Feline Liver Diseases","author":"WSAVA Liver Standardization Group","year":"2006"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14891"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i8.966"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/HMER.S7394"}],"container-title":["Veterinary Radiology &amp; Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vru.12969","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vru.12969","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vru.12969","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T08:36:57Z","timestamp":1693384617000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vru.12969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,14]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/vru.12969"],"URL":"https:\/\/doi.org\/10.1111\/vru.12969","archive":["Portico"],"relation":{},"ISSN":["1058-8183","1740-8261"],"issn-type":[{"value":"1058-8183","type":"print"},{"value":"1740-8261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,14]]},"assertion":[{"value":"2020-06-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}